CompoundsActive IngredientsEtomidate CAS 33125-97-2

Etomidate CAS 33125-97-2  Product Information

etomidate dose/etomidate dosage

Etomidate is a type of medication called a general anesthetic. It works by affecting the brain and nervous system to cause loss of consciousness and prevent pain during surgery or other procedures. Etomidate is given as an injection into a vein by a doctor or nurse. The dosage of etomidate depends on various factors, such as the patient’s age, weight, medical condition, and response to the medication. The usual adult dose for etomidate is 0.2 to 0.6 mg/kg given over 30 to 60 seconds. The usual pediatric dose for etomidate is 0.3 mg/kg given over 30 to 60 seconds. Etomidate should be used with caution in patients with heart problems, low blood pressure, adrenal insufficiency, or seizures.

etomidate mechanism of action

Etomidate works by binding to and activating a type of receptor in the brain and nervous system called the gamma-aminobutyric acid type A (GABA-A) receptor. This receptor is responsible for inhibiting the activity of nerve cells and producing sedation, relaxation, and anesthesia. By enhancing the effect of GABA-A receptors, etomidate reduces the transmission of pain signals and induces loss of consciousness. Etomidate also inhibits the production of a hormone called cortisol by the adrenal glands. Cortisol is involved in the body’s response to stress and inflammation. By lowering cortisol levels, etomidate may reduce the risk of complications during surgery or trauma. However, this effect may also cause side effects such as low blood pressure, nausea, vomiting, and adrenal insufficiency.

etomidate side effects

Etomidate may cause some side effects, such as:

• Low blood pressure
• Slow or irregular heartbeat
• Breathing problems
• Nausea and vomiting
• Involuntary muscle movements or twitching
• Pain or burning at the injection site
• Headache
• Dizziness
• Adrenal insufficiency (a condition where the adrenal glands do not produce enough hormones)
• Allergic reactions (such as rash, itching, swelling, or difficulty breathing)

etomidate vs propofol

Etomidate and propofol are both general anesthetics that work by affecting the GABA-A receptors in the brain and nervous system. However, they have some differences in their pharmacology, efficacy, and safety. Some of the main differences are:

Etomidate has a faster onset and shorter duration of action than propofol. Etomidate is usually used for induction of anesthesia (the initial phase of anesthesia where the patient loses consciousness), while propofol is used for both induction and maintenance of anesthesia (the phase where the patient remains unconscious during the procedure).
Etomidate has less effect on the cardiovascular system than propofol. Etomidate does not lower blood pressure or heart rate as much as propofol, which may be beneficial for patients with heart problems or low blood volume. However, etomidate may cause more irregular heartbeats than propofol.
Etomidate inhibits cortisol production more than propofol. Etomidate may cause adrenal insufficiency, especially with repeated or prolonged use. Propofol does not affect cortisol levels significantly, but it may increase the risk of infection or inflammation due to its immunosuppressive effects.
Etomidate causes more nausea and vomiting than propofol. Etomidate may also cause more pain or burning at the injection site and more involuntary muscle movements or twitching than propofol. Propofol may cause more headache and dizziness than etomidate.
Etomidate and propofol have similar risks of allergic reactions and breathing problems. Both medications should be used with caution in patients with allergies, asthma, or other respiratory conditions.
The choice between etomidate and propofol depends on various factors, such as the patient’s medical history, the type and duration of the procedure, and the availability and cost of the medications. Your doctor or anesthesiologist will decide which medication is best for you based on your individual situation.

what is etomidate

Etomidate is a type of medication called a general anesthetic. It works by affecting the brain and nervous system to cause loss of consciousness and prevent pain during surgery or other procedures. Etomidate is given as an injection into a vein by a doctor or nurse. The dosage of etomidate depends on various factors, such as the patient’s age, weight, medical condition, and response to the medication. Etomidate has some advantages and disadvantages compared to other anesthetics, such as propofol. Your doctor or anesthesiologist will explain more about etomidate and its possible side effects before giving it to you.

etomidate and succinylcholine

Etomidate and succinylcholine are two medications that are often used together during rapid sequence intubation (RSI). RSI is a technique where a tube is inserted into the patient’s airway to help them breathe during an emergency situation. Etomidate is used to induce anesthesia and succinylcholine is used to relax the muscles of the throat and chest. This combination allows for a quick and smooth intubation with minimal complications. However, etomidate and succinylcholine may also cause some side effects, such as low blood pressure, irregular heartbeat, adrenal insufficiency, nausea, vomiting, muscle pain, and increased eye pressure. These side effects should be monitored and treated by the medical staff during and after the procedure. Etomidate and succinylcholine should only be used by trained professionals in a hospital setting.