Research chemicalsIs D-Lysergic acid methyl ester a hallucinogen?

Lysergic acid methyl ester  product information

Overview

Lysergic acid methyl ester(CAS 4579-64-0) is an analogue of lysergic acid diethylamide (LSD). It is a member of the tryptamine family and is extremely uncommon. It acts on the 5-HT receptors in the brain, as do most tryptamines.

The following is its detailed product information:

• Product Name: D-Lysergic acid methyl ester
• Synonyms: D-Lysergic acid N,N-diethylamide tartrate; LSD tartrate,d; N,N-Diethyl-D-lysergamid-tartrate;D-Lysergic acid diethylamide tartrate; LSD 25 tartrate;6-methyl-9,10-didehydro-ergoline-8-carboxylic acid methyl ester; lysergic acid diethylamide bitartrate; Lysergide tartrate; D-LSD tartrate;lysergic acid methyl ester
• CAS NO: 4579-64-0
• EINECS: 224-964-9
• Molecular Formula: C17H18N2O2
• Molecular Weight: 282.34
• Melting point: 164-166 °C(Solv: benzene (71-43-2))
• Boiling point: 469.0±45.0 °C(Predicted)
• Density: 1.30±0.1 g/cm3(Predicted)
• Appearance: White powder

A process for preparing lysergic acid esters of the formula R’COOR wherein R is alkyl of up to 3 carbon atoms, comprises reacting corresponding lysergic acid or isolysergic acid amides with corresponding alcohols at temperatures of 0 deg. to 65 deg. C. for 2 to 30 hours in the presence of acid at a pH value of 0-1.

Of course, this is only a method in the traditional sense, and more experiments are needed to confirm the specific operation.

Application

D-Lysergic Acid Methyl Ester is used in preparing Serotonin agonists. It is an impurity of Lysergic Acid (L488000). Lysergic Acid and Iso-lysergic Acid are the primary cleavage products formed on alkaline hydrolysis of the alkaloids which are characteristic of ergot. Potent hallucinogen; non-selective serotonin receptor agonist.

Currently known uses are:

1. Hallucinogens
2. Serotonin receptor modulators
3. Ergolines

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