Is D-Lysergic acid methyl ester a hallucinogen?


Lysergic acid methyl ester(CAS 4579-64-0) is an analogue of lysergic acid diethylamide (LSD). It is a member of the tryptamine family and is extremely uncommon. It acts on the 5-HT receptors in the brain, as do most tryptamines.

D-Lysergic acid methyl ester CAS 4579-64-0

Detailed product information

The following is its detailed product information:

  • Product Name: D-Lysergic acid methyl ester
  • Synonyms: D-Lysergic acid N,N-diethylamide tartrate; LSD tartrate,d; N,N-Diethyl-D-lysergamid-tartrate;D-Lysergic acid diethylamide tartrate; LSD 25 tartrate;6-methyl-9,10-didehydro-ergoline-8-carboxylic acid methyl ester; lysergic acid diethylamide bitartrate; Lysergide tartrate; D-LSD tartrate;lysergic acid methyl ester
  • CAS NO: 4579-64-0
  • EINECS: 224-964-9
  • Molecular Formula: C17H18N2O2
  • Molecular Weight: 282.34
  • Melting point: 164-166 °C(Solv: benzene (71-43-2))
  • Boiling point: 469.0±45.0 °C(Predicted)
  • Density: 1.30±0.1 g/cm3(Predicted)
  • Appearance: White powder

CAS 4579-64-0

A process for preparing lysergic acid esters of the formula R’COOR wherein R is alkyl of up to 3 carbon atoms, comprises reacting corresponding lysergic acid or isolysergic acid amides with corresponding alcohols at temperatures of 0 deg. to 65 deg. C. for 2 to 30 hours in the presence of acid at a pH value of 0-1.

Of course, this is only a method in the traditional sense, and more experiments are needed to confirm the specific operation.


D-Lysergic Acid Methyl Ester is used in the preparation of Serotonin agonists. It is an impurity of Lysergic Acid (L488000). Lysergic Acid and Iso-lysergic Acid are the main cleavage products formed on alkaline hydrolysis of the alkaloids which are characteristic of ergot. Potent hallucinogen; non-selective serotonin receptor agonist.

Currently known uses are:

  1. Hallucinogens
  2. Serotonin receptor modulators
  3. Ergolines
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