Tryptamine is a monoamine alkaloid that can be synthesized by decarboxylation of the amino acid tryptophan. Notably, tryptamine can be found in fungi, plants, Amphibia, animals, and microbes.Tryptamine is a monoamine alkaloid, similar to other trace amines, considered a neuromodulator or neurotransmitter.
Tryptamine CAS 61-54-1 Product Information
|Synonyms:||2-(1H-Indol-3-yl)ethylamine;Tryptamine;1H-Indole-3-ethanamine;2-indol-3-yl-ethylamine;Indole-ethylamine;L-TRYPTAMINE;EINECS 200-510-5;2-Indol-3-yl-aethylamin;Tryptamin;3-Indoleethanamine;2-(1H-Indol-3-yl)ethanamine;MFCD00005661;TRYPTAMINE(P);125513;T56 BMJ D2Z;[2-(1H-indol-3-yl)-ethyl]amine;TRIPTAMINE;(1H-indol-3-yl)ethanamine;2-indol-3-ylethylamine|
|Boiling Point:||137 °C/0.15 mmHg (lit.)|
|Melting point:||113-116 °C (lit.)|
|Density:||0.9787 (rough estimate)|
|Appearance:||White or pale yellow powder|
|Solubility:||Store in a dry place at 4°C.|
|Storage:||slightly soluble in water|
What is tryptamine?
Tryptamine is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter.It is an aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is an aminoalkylindole, an indole alkaloid, an aralkylamino compound and a member of tryptamines. It is a conjugate base of a tryptaminium.
What is tryptamine used for?
Tryptamine has been shown to activate trace amine-associated receptors expressed in the mammalian brain, and regulates the activity of dopaminergic, serotonergic and glutamatergic systems.In the human gut, symbiotic bacteria convert dietary tryptophan to tryptamine, which activates 5-HT4 receptors and regulates gastrointestinal motility.Multiple tryptamine-derived drugs have been developed to treat migraines, while trace amine-associated receptors are being explored as a potential treatment target for neuropsychiatric disorders.
Tryptamine in plants is the entry point to metabolic routes leading to the synthesis of indole alkaloids such as vincristine and vinblastine, which have been widely studied in the context of medicine and pharmacology.
Tryptamine, a monoamine alkaloid containing an indole ring structure is derived by the decarboxylation of amino acid tryptophan.
The synthesis of tryptamines is typically conducted following a classic route starting with a Mannich reaction of an indole heterocycle, followed by quaternization of the amine, nucleophilic substitution with highly toxic cyanide and final reduction.
Tryptamine is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of tryptamine in these solvents is approximately 10, 11, and 5 mg/ml, respectively. Tryptamine is sparingly soluble in aqueous buffers.
1 review for Tryptamine CAS 61-54-1
06/27/2022 at 5:10 AM
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