Flibanserin Hcl CAS 147359-76-0 › Wuhan WinGroup Chemical

Flibanserin Hydrochloride

CAS: 147359-76-0

MF: C20H22ClF3N4O

Flibanserin (BIMT-17; BIMT-17BS) hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research[1]-[5].

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Flibanserin Hydrochloride CAS 147359-76-0 Product Information

Product Name:	Flibanserin Hydrochloride
Synonyms:	Flibanserin Hydrochloride;Flibanserin HCl;Flibanserin iMpurity;2H-Benzimidazol-2-one,1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-,hydrochloride (1:1);Flibanserin Hydrochloride USP/EP/BP;2H-Benzimidazol-2-one,1,3-dihydro-1-[2-[4-[3-(trifluoromethy…;1-(2-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one hydrochloride
CAS NO:	147359-76-0
Molecular Weight:	426.87
Molecular Formula:	C20H22ClF3N4O
Melting point:	>225°C (dec.)
Appearance:	White to Pale Yellow Solid
Applications:	Flibanserin is a 5-HT1A agonist and 5-HT2A antagonist that is developed for the treatment of hypoactive sexual desire disorder in women.
Solubility:	DMSO (Slightly), Methanol (Slightly)
Storage:	Inert atmosphere,Room Temperature

what is flibanserin used for

Flibanserin is used to treat women with hypoactive sexual desire disorder (HSDD; a low sexual desire that causes distress or interpersonal difficulty) who have not experienced menopause (change of life; the end of monthly menstrual periods).

how does flibanserin work

Flibanserin works by enhancing 5-HT1A (putting on the brakes) and inhibiting 5-HT2A (stopping acceleration). Between the two, serotonin production is heavily downregulated.

does flibanserin work

Flibanserin doesn’t work for everybody. But 46-60% of women with HSDD, or a little more than half, reported clear benefit from flibanserin in randomized placebo-control clinical trials.