Flibanserin Hydrochloride
CAS: 147359-76-0
MF: C20H22ClF3N4O
Flibanserin (BIMT-17; BIMT-17BS) hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research[1]-[5].
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Flibanserin Hydrochloride CAS 147359-76-0 Product Information
| Product Name: | Flibanserin Hydrochloride |
| Synonyms: | Flibanserin Hydrochloride;Flibanserin HCl;Flibanserin iMpurity;2H-Benzimidazol-2-one,1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-,hydrochloride (1:1);Flibanserin Hydrochloride USP/EP/BP;2H-Benzimidazol-2-one,1,3-dihydro-1-[2-[4-[3-(trifluoromethy…;1-(2-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one hydrochloride |
| CAS NO: | 147359-76-0 |
| Molecular Weight: | 426.87 |
| Molecular Formula: | C20H22ClF3N4O |
| Melting point: | >225°C (dec.) |
| Appearance: | White to Pale Yellow Solid |
| Applications: | Flibanserin is a 5-HT1A agonist and 5-HT2A antagonist that is developed for the treatment of hypoactive sexual desire disorder in women. |
| Solubility: | DMSO (Slightly), Methanol (Slightly) |
| Storage: | Inert atmosphere,Room Temperature |
what is flibanserin used for
Flibanserin is used to treat women with hypoactive sexual desire disorder (HSDD; a low sexual desire that causes distress or interpersonal difficulty) who have not experienced menopause (change of life; the end of monthly menstrual periods).
how does flibanserin work
Flibanserin works by enhancing 5-HT1A (putting on the brakes) and inhibiting 5-HT2A (stopping acceleration). Between the two, serotonin production is heavily downregulated.
does flibanserin work
Flibanserin doesn’t work for everybody. But 46-60% of women with HSDD, or a little more than half, reported clear benefit from flibanserin in randomized placebo-control clinical trials.
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| Color | White |
|---|---|
| Form | Powder |
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