Flibanserin (BIMT-17; BIMT-17BS) hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-.
- Additional information
Flibanserin Hydrochloride CAS 147359-76-0 Product Information
|Product Name:||Flibanserin Hydrochloride|
|Synonyms:||Flibanserin Hydrochloride;Flibanserin HCl;Flibanserin iMpurity;2H-Benzimidazol-2-one,1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-,hydrochloride (1:1);Flibanserin Hydrochloride USP/EP/BP;2H-Benzimidazol-2-one,1,3-dihydro-1-[2-[4-[3-(trifluoromethy…;1-(2-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one hydrochloride|
|Melting point:||>225°C (dec.)|
|Appearance:||White to Pale Yellow Solid|
|Applications:||Flibanserin is a 5-HT1A agonist and 5-HT2A antagonist that is developed for the treatment of hypoactive sexual desire disorder in women.|
|Solubility:||DMSO (Slightly), Methanol (Slightly)|
|Storage:||Inert atmosphere,Room Temperature|
what is flibanserin used for
Flibanserin is used to treat women with hypoactive sexual desire disorder (HSDD; a low sexual desire that causes distress or interpersonal difficulty) who have not experienced menopause (change of life; the end of monthly menstrual periods).
how does flibanserin work
Flibanserin works by enhancing 5-HT1A (putting on the brakes) and inhibiting 5-HT2A (stopping acceleration). Between the two, serotonin production is heavily downregulated.
does flibanserin work
Flibanserin doesn’t work for everybody. But 46-60% of women with HSDD, or a little more than half, reported clear benefit from flibanserin in randomized placebo-control clinical trials.