Sex Raw MaterialDapoxetine hydrochloride CAS 129938-20-1


Dapoxetine hydrochloride



It belonging to the class of SSRIs, was the first drug originally approved for the on-demand treatment of men with PE by seven European countries in 2008.
Premature ejaculation (PE) is the most common male sexual dysfunction. It is a short-acting SSRI. It is differentiated from the existing SSRI treatments for PE by the fact that it can be administered on an as-needed basis.

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Dapoxetine hydrochloride CAS 129938-20-1 Product Information

Product Name: Dapoxetine hydrochloride
Synonyms: N-Dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride;S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, LY-210448 hydrochloride;(1s)-n,n-dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride;Rimonabant 75000;(aS)-N,N-Dimethyl-a-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine;LY-21044;((S)-(+)-N,N-Dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride)
CAS NO: 129938-20-1
Molecular Weight:  341.874
Molecular Formula: C21H24ClNO
Boiling Point: 454.4ºC at 760 mmHg
Melting point: 175-179ºC
Appearance: White power
Applications: It is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men.
Storage:  room temp

tadalafil & dapoxetine hydrochloride tablets

Tadalafil and dapoxetine hydrochloride tablets are a combination medication used to treat two different conditions: erectile dysfunction (ED) and premature ejaculation (PE).

Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor. It works by increasing blood flow to the penis, helping to achieve and sustain an erection. Tadalafil is commonly marketed under the brand name Cialis.

Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) that is specifically approved for the treatment of premature ejaculation. It helps to delay ejaculation and improve control over ejaculation.

The combination of tadalafil and dapoxetine hydrochloride in a single tablet is intended for men who experience both ED and PE, addressing both conditions simultaneously.

It’s important to note that these medications should be taken under the supervision and guidance of a healthcare professional. They may have potential side effects and drug interactions, and the dosage and duration of treatment should be determined by a qualified healthcare provider based on individual needs and medical history.

Dapoxetine hydrochloride side effects

  • Dizziness.
  • Nervousness and confusion.
  • Excessive sweating.
  • Headache.
  • Diarrhoea.
  • Decreased libido.
  • Blurred vision.
  • Ringing or buzzing in the ears.

Dapoxetine hydrochloride Synthesis

It can be synthesized in four chemical steps starting from R-1phenyl- 1,3-propanediol via selective tosylation of the primary hydroxy group with p-toluenesulfonyl chloride, triethylamine and 4-(dimethylamino) pyridine (DMAP), and subsequent condensation with 1naphthol by means of sodium- or lithium hydroxide to yield R-3-(1naphthyloxy)- 1-phenylpropanol as the key intermediate. Conversion of the alcohol group to the corresponding mesylate with methanesulfonyl chloride, triethylamine, and DMAP, followed by treatment with dimethylamine affords it, which is then acidified to its hydrochloride salt.

Dapoxetine hydrochloride uses/what is Dapoxetine hydrochloride used for

It is used to treat premature ejaculation in adult men aged 18-64years. It works by increasing the serotonin level in the nervous system; this increases the time it takes to ejaculate and could improve control over ejaculation.

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