CAS: 112809-51-5
MF: C17H11N5
Letrozole is part of a new generation of highly selective aromatase inhibitors and is an artificially synthesized benzotriazole derivative. Letrozole inhibits aromatase to lower estrogen levels, thus preventing estrogen from stimulating tumor growth. Its in vivo activity is 150-250 times stronger than that of first generation aromatase inhibitor Amarante. As it is highly selective, it will not impact glucocorticoid, mineralocorticoid and thyroid functions; even at high dosages, it will not have any inhibiting effects on adrenal corticosteroid secretion, giving it a high treatment index.
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Letrozole CAS 112809-51-5 Product Information
| Product Name: | Letrozole |
| Synonyms: | LetrozoleUsp28;Letrozole99%;CGS-20267, Femara;LETRAZOLE;letrozolex;Lelrozol;1-[BIS(4-CYANOPHENYL)METHYL]-1,2,4-TRIAZOLE;4,4′-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile |
| CAS NO: | 112809-51-5 |
| Molecular Weight: | 285.3 |
| Molecular Formula: | C17H11N5 |
| Boiling Point: | 563.5±60.0 °C(Predicted) |
| Melting point: | 181-183°C |
| Density: | 1.21±0.1 g/cm3(Predicted) |
| Appearance: | White powder |
| Uses: | Letrozole has been used: in organoid growth assay to determine its inhibitory capacity(48) to investigate steroid receptor coactivator-1 (SRC-1) mediated endogenous estrogen regulation of hippocampal PSD-95(49) to determine its effects on tumor-induced hyperalgesia(50) for hormonal manipulation in rats(51) to study its effects on lipocalin-2 (Lcn2)(52) to determine its effects on mechanical hyperalgesia and aromatase expression(53) |
| Solubility: | DMSO: >50mg/mL |
| Storage: | 2-8°C |
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| Color | White to offwhite |
|---|---|
| Form | Powder |
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