Lacosamide (LCM), (SPM 927, (R)-2-acetamido-N-benzyl-3-methoxypropionamide, previously referred to as harkoseride or ADD 234037) is a member of a series of functionalized amino acids that were specifically synthesized as anticonvulsant or antiepileptic drug. It reduces the spread of seizure activity in the brain.
LACOSAMIDE CAS 175481-36-4 Product Information
|Synonyms:||LACOSAMIDE;(2R)-2-(Acetylamino)-3-methoxy-N-(phenylmethyl)propanamide;ADD 243037;Harkoseride;SPM 927;(2R)-N-benzyl-2-acetaMido-3-MethoxypropanaMide;LacosaMide (1.0Mg/ML in Acetonitrile);(R)-2-Acetamido-N-benzyl-3-methoxypropionamide|
|Boiling Point:||536.4±50.0 °C(Predicted)|
|Appearance:||White to Off-White Solid|
|Solubility:||DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 2 mg/ml|
Lacosamide is a medication that is primarily used for the treatment of epilepsy, specifically as an adjunctive (add-on) therapy for partial-onset seizures in adults and children aged 4 years and older. Here are some key uses of lacosamide:
- Partial-onset seizures: Lacosamide is approved for the treatment of partial-onset seizures in people with epilepsy. Partial-onset seizures are characterized by abnormal electrical activity that starts in a specific area of the brain, leading to symptoms such as altered consciousness, repetitive movements, sensory changes, or emotional disturbances. Lacosamide is used as an additional treatment alongside other antiepileptic medications to help control these seizures.
- Monotherapy: Lacosamide can also be prescribed as a monotherapy, which means it can be used as the sole antiepileptic medication for individuals with partial-onset seizures who are starting epilepsy treatment or switching from other medications.
lacosamide mechanism of action
Lacosamide is an antiepileptic medication that is used for the treatment of partial-onset seizures in individuals with epilepsy. Its mechanism of action involves modulation of sodium channels in the brain. Here’s an explanation of the mechanism of action of lacosamide:
- Enhancement of slow inactivation of sodium channels: Lacosamide selectively enhances the slow inactivation of voltage-gated sodium channels in the brain, particularly the sodium channel subtype known as Nav1.3. This mechanism is thought to contribute to its antiepileptic effects. By enhancing slow inactivation, lacosamide helps stabilize the activity of hyperexcitable neurons, reducing their abnormal firing and the spread of seizure activity in the brain.
- Modulation of calcium channels: Lacosamide may also have an effect on calcium channels in the brain, although the exact details of this modulation are not fully understood. It is believed that lacosamide may interact with certain calcium channel subtypes, potentially altering calcium currents and neuronal excitability.
By modulating sodium and possibly calcium channels, lacosamide helps to regulate the electrical activity of neurons in the brain, which can reduce the occurrence and severity of seizures. It is important to note that the precise mechanisms by which lacosamide exerts its clinical effects are still the subject of ongoing research.
is lacosamide a controlled substance
No, lacosamide is not classified as a controlled substance. Controlled substances are drugs that are regulated by the government due to their potential for abuse or addiction. Examples of controlled substances include opioids, stimulants, and certain sedatives. Lacosamide is an antiepileptic medication and does not have a significant potential for abuse or addiction. However, it is still a prescription medication and should only be used under the supervision and prescription of a healthcare professional.