CompoundsActive IngredientsLACOSAMIDE CAS 175481-36-4

SKU: WGP-175481-36-4



Molecular Formula: C13H18N2O3
Molecular Weight: 250.29
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LACOSAMIDE CAS 175481-36-4 Product Information

Product Name: LACOSAMIDE
Synonyms: LACOSAMIDE;(2R)-2-(Acetylamino)-3-methoxy-N-(phenylmethyl)propanamide;ADD 243037;Harkoseride;SPM 927;(2R)-N-benzyl-2-acetaMido-3-MethoxypropanaMide;LacosaMide (1.0Mg/ML in Acetonitrile);(R)-2-Acetamido-N-benzyl-3-methoxypropionamide
CAS NO: 175481-36-4
Molecular Weight: 250.29
Molecular Formula:  C13H18N2O3
Boiling Point: 536.4±50.0 °C(Predicted)
Melting point: 141-143?C
Density: 1.120±0.06 g/cm3(Predicted)
Appearance: White to Off-White Solid
Purity: >98%
Solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 2 mg/ml
Storage:  Refrigerator

lacosamide uses

Lacosamide is a pharmaceutical predominantly prescribed for the management of epilepsy, particularly as an additional therapy for partial-onset seizures in adults and children aged 4 years and above. Below are several primary applications of lacosamide:

1. Lacosamide is authorized for the management of partial-onset seizures in individuals diagnosed with epilepsy. Partial-onset seizures are distinguished by atypical electrical activity that originates in a particular region of the brain, resulting in symptoms such as modified awareness, repetitive motions, sensory alterations, or emotional disruptions. Lacosamide is administered as an adjunctive therapy in conjunction with other antiepileptic drugs to aid in the management of these seizures.
2. Monotherapy: Lacosamide may be used as a monotherapy, serving as the only antiepileptic medicine for persons with partial-onset seizures who are initiating epilepsy treatment or transitioning from previous medications.

lacosamide mechanism of action

Lacosamide is an antiepileptic drug prescribed to persons with epilepsy to treat partial-onset seizures. The mechanism of action of this substance includes the regulation of sodium channels in the brain. Below is a detailed elucidation of the process by which lacosamide exerts its effects:

1. Lacosamide specifically promotes the delayed inactivation of voltage-gated sodium channels in the brain, particularly the Nav1.3 subtype. This is believed to be the reason for its antiepileptic benefits. Lacosamide stabilizes the activity of hyperexcitable neurons by promoting delayed inactivation, so lowering their aberrant firing and the propagation of seizure activity in the brain.
2. Lacosamide may exert an influence on calcium channels in the brain, however the precise mechanisms of this regulation remain incompletely elucidated. Lacosamide is thought to have the ability to interact with specific subtypes of calcium channels, which could potentially modify calcium currents and the excitability of neurons.

Lacosamide modulates sodium and potentially calcium channels to regulate the electrical activity of neurons in the brain, hence decreasing the frequency and intensity of seizures. The specific pathways through which lacosamide produces its therapeutic effects are still being actively investigated.

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About After Sales Within 7 days of your receipt of the goods if you find any problems with the goods (broken packaging, less hair, etc.) please feel free to contact our sales, we will help you deal with it in time.


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