Exemestane
CAS:107868-30-4
MF: C20H24O2
Exemestane was launched in US and other countries for the treatment of estrogendependent tumors and postmenopausal breast cancer. It is a novel steroidal compound structurally related to the natural substrate for the biosynthesis of estrogen, androstanedione, and can be synthesized by methylidenation of androsta-1, 4-dien- 17beta-ol-3-one in 6 position then oxidation of the alcohol function. Exemestane is an irreversible inactivator of the aromatase enzyme system, so inducing in vivo a dose-related sustained suppression of serum estrogen and minimal endocrine activity.
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Exemestane CAS 107868-30-4 Product Information
Product Name: | Exemestane |
Synonyms: | ExeMestane (USP);ExeMestane(AroMasin);1,4-Androstadien-3,17-dione-6-Methylene-d2;(8R,9S,10R,13S,14S)-10,13-Dimethyl-6-methylene-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17(10H,14H)-dione;ExeMestine;(8R,9S,10R,13S,14S)-10,13-diMethyl-6-Methylene-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione;ExeMestane SynonyMs 6-Methylenandrosta-1,4-diene-3,17-dione;PNU155971 |
CAS NO: | 107868-30-4 |
Molecular Weight: | 296.4 |
Molecular Formula: | C20H24O2 |
Boiling Point: | 453.7±45.0 °C(Predicted) |
Melting point: | 155.13°C |
Density: | 1.13±0.1 g/cm3(Predicted) |
Appearance: | white to off-white powder |
Applications: | Exemestane is a steroidal antiestrogen and irreversible aromatase inhibitor. Exemestane acts as a false substrate for the aromatase enzyme. Exemestane also prevents the conversion of androgens to estrogens and is used to treat estrogen-dependent breast cancer.. |
Solubility: | DMSO: ≥20mg/mL |
Storage: | 2-8°C |
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Color | White to offwhite |
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Form | Powder |
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