Pramlintide CAS NO 196078-30-5

SKU: WGP-196078-30-5

CAS 196078-30-5
MF: C173H273N51O56S2
FW: 4027.46
  • Description
  • Additional information


CAS NO: 196078-30-5
Product Name: Pramlintide acetate
Synonyms: AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE;pramlintide acetate;pramlintide acetate hydrate;25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate;AC-137 Acetate Hydrate, SyMlin Acetate Hydrate;Tripo-aMylin Acetate Hydrate;Pramlintide Acetate, Amylin Rat;Pramlintide acetate fandachem
Molecular Formula: C173H273N51O56S2
Molecular Weight: 4027.46
Melting point: >175°C (dec.)
Solubility: Acetic Acid (Slightly), DMSO (Slightly)
Storage: Refrigerator
Appearance: White to Off-White Solid
Purity: >98%


Pramlintide acetate is an injectable human amylin analog that has been launched for the treatment of both type 1 and type 2 diabetes, in conjunction with insulin. While it is also a 37-amino acid peptide, it differs from its parent predecessor by the substitution of Ala-25, Ser-28, and Ser-29 with prolines. Not only do these modifications improve the solubility of the peptide, they also eliminate the aggregation observed with amylin, resulting in a stable synthetic analog with retention of biological activity that is suitable for pharmaceutical use. As an indication of potency, Pramlintide acetate inhibits the binding of radioiodinated rat amylin to rat nucleus accumbens membranes with a Ki value of 23 pM. Its mechanism of action mimics amylin; as a neurohormone that is cosecreted with insulin from the pancreatic β cells in response to meals, it is involved in glucose homeostasis. Both peptides lower postprandial glucose levels by inhibiting glucagon and by restraining the vagus-mediated rate of gastric emptying, thereby, slowing intestinal carbohydrate absorption. Furthermore, amylin, orPramlintide acetate, has the added benefit of inducing postprandial satiety resulting in weight loss in the patients with type 2 diabetes. Since Pramlintide acetate slows gastric emptying, it is contraindicated in patients with gastroparesis and in patients taking drugs that alter gastrointestinal motility (anticholinergic agents, such as, atropine) or slow down the intestinal absorption of nutrients (such as α-glucosidase inhibitors). Pramlintide acetate is also contraindicated in patients with hypoglycemic tendencies; due to co-administration with insulin, severe insulin-induced hypoglycemia is a risk. The most commonly reported adverse events include nausea, vomiting, anorexia, headache, abdominal pain, fatigue, dizziness, coughing, and pharyngitis.


Pramlintide acetate is an analogue of human amylin used in the treatment of insulin dependent diabetes.

Additional information


White to offwhite


Crystal powder


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