Desmopressin (Brand name: DDAVP) is an artificial derivative of vasopressin, being similar to the antidiuretic hormone (ADH) that naturally produced in the body. It is used for the treatment of diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease and high blood urea levels. It is capable of increasing the water permeability in the renal tubular cells, further increasing the urine concentration and decreasing the urine production.
- Additional information
Desmopressin CAS 129938-20-1 Product Information
|Synonyms:||MPR-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2;MINIRIN;[DEAMINO1, DARG8] VASOPRESSIN;[DEAMINO-CYS1, D-ARG8]-VASOPRESSIN;DDAVP, HUMAN;DESMOPRESSIN;DESMOPRESSIN, HUMAN;DESAMINO-[D-ARG8]VASOPRESSIN|
|Solubility:||H2O: soluble20mg/mL, clear, colorless|
|Appearance:||White or almost white, fluffy powder|
|Applications:||[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was used to study the impact of vasopressin on pendrin abundance. E3 ubiquitin (Ub)-protein ligases (E3s) was administered in rat kidney and the changes in protein abundance of the selected E3s in response to [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was examined.|
|Storage:||Store at 0°C|
desmopressin side effects
Desmopressin, like any medication, can cause side effects in some individuals. Common side effects of desmopressin acetate may include:
Abdominal pain or cramps
Flushing (redness and warmth of the skin)
Runny or stuffy nose
Water retention or swelling
These side effects are typically mild and temporary. However, it’s important to contact your healthcare provider if any side effects are severe, persistent, or concerning.
Here are some key uses of desmopressin acetate:
Diabetes Insipidus: Desmopressin is commonly prescribed for the treatment of diabetes insipidus, a condition characterized by excessive thirst and urination. It helps reduce urine production and control fluid balance by acting on the kidneys.
Nocturnal Enuresis: Desmopressin is also used to treat nocturnal enuresis, which is bedwetting that occurs during sleep. It helps reduce nighttime urine production and can be administered as a nasal spray, tablet, or in a sublingual form.
Hemophilia A and von Willebrand Disease: In certain cases of hemophilia A and von Willebrand disease (a bleeding disorder), desmopressin can be used to enhance the release of clotting factors and improve blood clotting ability.
desmopressin acetate/what is desmopressin
Desmopressin acetate, also known as desmopressin or DDAVP (1-deamino-8-D-arginine vasopressin), is a synthetic analogue of the hormone vasopressin. It is primarily used for the treatment of several medical conditions related to fluid balance and urine production.
desmopressin vs vasopressin
Desmopressin and vasopressin are two related hormones, but they have some differences in their actions, uses, and formulations.
Action: Vasopressin, also known as antidiuretic hormone (ADH), is naturally produced by the hypothalamus and released by the pituitary gland. It acts on the kidneys to increase water reabsorption and decrease urine production, helping to maintain fluid balance in the body. Desmopressin is a synthetic analogue of vasopressin that has a similar action but with a longer duration of action.
Uses: Vasopressin is primarily used in emergency situations, such as cardiac arrest, to increase blood pressure and blood flow to vital organs. It may also be used in the treatment of diabetes insipidus, a condition characterized by excessive thirst and urination due to a deficiency or resistance to vasopressin. Desmopressin, on the other hand, is commonly used for the treatment of diabetes insipidus, as well as for other conditions such as bedwetting (nocturnal enuresis) and certain bleeding disorders.
Formulations: Vasopressin is available in injectable forms for immediate use in emergency situations. Desmopressin is available in various formulations, including nasal spray, tablets, sublingual tablets, and injectable forms. The different formulations of desmopressin allow for different routes of administration depending on the specific condition being treated.
Duration of Action: Vasopressin has a relatively short duration of action and is rapidly metabolized in the body. Desmopressin, being a synthetic analogue, has a longer duration of action, allowing for less frequent dosing in many cases.
It’s important to note that both desmopressin and vasopressin should be used under the guidance and supervision of a healthcare professional. The specific choice of medication and its appropriate use will depend on the individual’s medical condition, the desired therapeutic effect, and other factors considered by the healthcare provider.
The dosage of desmopressin acetate depends on the condition being treated and the patient’s response. For example, for diabetes insipidus in infants 3 months of age to children 12 years of age, the usual dose is 5 mcg/day as a single dose or in 2 divided doses. The dose range is 5 to 30 mcg/day.
For adults and children 6 years of age or older with bed-wetting, the usual dose is 0.2 milligram (mg) as a single dose at bedtime. The dose may be adjusted as needed but usually not more than 0.6 mg per day.
It is important to note that the dosage may vary depending on the patient’s condition and response. Therefore, it is important to consult with your doctor before taking this medication.
desmopressin mechanism of action
Desmopressin acetate works by binding to vasopressin receptors in the kidneys, leading to reduced urine production and increased water reabsorption. It has a longer duration of action compared to natural vasopressin.
desmopressin for dogs
Desmopressin can also be used in veterinary medicine for certain conditions in dogs. In dogs, desmopressin is primarily used to manage central diabetes insipidus, a condition characterized by the inability to concentrate urine due to a deficiency or resistance to vasopressin.
desmopressin bleeding/desmopressin hemophilia
Desmopressin can be used in certain bleeding disorders to help increase clotting factors and improve blood clotting ability. It is commonly used in conditions such as mild hemophilia A and von Willebrand disease.
desmopressin for bedwetting
Desmopressin can be used in the treatment of primary nocturnal enuresis, which is bedwetting that occurs during sleep, in children and adolescents. It helps reduce nighttime urine production and can be an effective treatment option.
desmopressin dosage for bedwetting
For bedwetting in adults and children 6 years of age or older, the usual dose of desmopressin is 0.2 milligram (mg) as a single dose at bedtime. The dose may be adjusted as needed but usually not more than 0.6 mg per day.
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