- Additional information
|Synonyms:||Plecanatide;ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4);Plecanatide Impurtiy;L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide);Plecanatide fandachem;Plecanatide impurity;Plecanatide USP/EP/BP;Prikanatide|
|Boiling point:||2120.0±65.0 °C(Predicted)|
|Shipping Condition:||Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.|
|Storage Condition:||Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Solubility:||Soluble in DMSO|
Plecanatide is an analog of uroguanylin, an orally active guanylate cyclase-C (GC-C) receptor agonist, in T84 cells, EC50 value 190 nM. Plecanatide can be used in the study of chronic idiopathic constipation and has anti-inflammatory activity in mouse colitis models.
Plecanatide is used in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a laxative by drawing water in to the gastrointestinal tract thereby softening stool and encouraging its natural passage.
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