Glatiramer Acetate CAS NO 147245-92-9

SKU: WGP-147245-92-9

CAS 147245-92-9
MF: C25H45N5O13
FW: 623.66
  • Description
  • Additional information

Description

CAS NO 147245-92-9
Chemical Name Glatiramer acetate
Synonyms ProtiraMer;GlatiraMer-d7;GaltiraMer acetate;GLATIRAMER ACETATE;Glatiramer acetate USP/EP/BP;Glatiramer acetate [USAN:BAN];Pharmaceutical Glatiramer acetate;511: PN: WO2010103292 PAGE: 64 claiMed sequence;L-Alanine polyMer with L-GlutaMic Acid L-Lysine L-Tyrosine Acetate;L-Tyrosine polyMer with L-Alanine L-GlutaMic Acid L-Lysine Acetate
Molecular Formula C25H45N5O13
Formula Weight 623.66
Purity ≥95%
Appearance A crystalline solid
Solubility PBS (pH 7.2): 1 mg/ml
Storage -20°C
Shipping Room Temperature in continental US; may vary elsewhere
Stability ≥ 2 years

Description

Glatiramer (acetate) is a mixture of synthetic polypeptides composed of four amino acids found in myelin basic protein (MBP): L-Alanine, L-glutamic acid, L-lysine, and L-tyrosine. It prevents MBP from binding to MHC class II molecules in the periphery and induces the production of immunomodulatory molecules considered to be anti-inflammatory. It also increases proliferation of oligodendrocyte and neuronal precursor cells in the central nervous system of mice. Formulations containing glatiramer (acetate) are used to treat patients with multiple sclerosis, particularly the relapsing-remitting type.

Originator:

Copaxone,Teva Pharmaceuticals,Israel

Uses:

Glatiramer acetate is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine in a molar ratio of 6:1.9:4.7:1. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis.

Manufacturing Process:

Glatiramer Acetate is water soluble copolypeptide with molecular weight 15,000-25,000.

Copolymer is prepared by copolymerization of the N-carboxyanhydrides of tyrosine, alanine, lysine, and glutamic acid. The polymerisation was carried out at ambient temperature in anhydrous dioxane with diethylamine as initiator. Glatiramer Acetate have the ratio alanin:glutamic acid:lysine:tyrosine = 1:6:4.54:2.

Therapeutic Function:

Immunomodulator

Additional information

Color

White

Form

Crystal powder

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