- Additional information
|Boiling point:||959.8±65.0 °C(Predicted)|
|Solubility:||Soluble in DMSO, not in water|
|Storage:||Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Appearance:||Lyophilized White Powder|
|Shipping Condition:||Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.|
Epitalon is a synthetic polypeptide called epithelial vitamin, which is identified as the putative active component of a bovine pineal gland extract known as epithalamin. Epitalon is a tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly. Epitalon decreases the age-related changes in immune and neuroendocrine systems, reduces the incidence of recurrent infections and chronic diseases. Epitalon appears to induce telomere elongation via increased telomerase activity in human somatic cells in vitro. Epitalon appears to inhibit the synthesis of the MMP9 protein in vitro in aging skin fibroblasts. Lower levels of DNA damage were observed in senescence-accelerated mice (SAMP-1) treated with epithalon. Several studies suggest that epithalon may cross the blood-brain barrier, where it may stimulate cortical neurons and increase levels of phosphor-CREB, a DNA-binding protein important in learning and memory.
Epitalon is an anti-aging agent and telomerase activator. Epitalon has an inhibitory effect on the development of spontaneous tumors in mice, has a geroprotective effect, and can increase neuronal activity through intranasal administration. Epitalon can be used for cancer, aging and retinitis pigmentosa.