- Additional information
|Synonyms||4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile; 4-[1-(4-Cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile; CGS 20267; Femara; Lerozole; Letrazole;|
|Appearance||White to Off-White Solid|
|Solubility||Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)|
|Category||Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications||A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic.|
Letrozole is an inhibitor of aromatase that prevents the formation of estrogens; it is clinically used to treat hormone-responsive breast cancer and infertility and to terminate pregnancy. Letrozole exhibits anticancer chemotherapeutic and anti-estrogenic activities. In vivo, letrozole increases secretion of luteinizing hormone (LH), lengthens the follicular dominance period, and delays subsequent follicular waves.
Please note that all purities are given on a dry basis. The purity does not include water or solvent that may be present. These quantities will be listed separately on the COA when applicable