Anastrozole
CAS: 120511-73-1
MF: C17H19N5
Anastrozole is a potent selective triazole aromatase inhibitor that inhibits the aromatase that cytochrome P-450 is dependent on to prevent the biosynthesis of estrogen. Estrogen is the main stimulating factor for breast cancer cell growth. This drug’s half maximal inhibitory concentration (IC50) value to human placental aromatase is 15nmol/L. Compared to the traditional drug tamoxifen, Anastrozole can comprehensively and effectively lower the risks of breast cancer recurrence and metastasis, thus extending patients’ disease-free survival.
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Description
Anastrozole CAS 120511-73-1 Product Information
| Product Name: | Anastrozole |
| Synonyms: | ICI-D-1033;ARIMIDEX;1-[3,5-DI-(1-METHYL-1-CYANO)-ETHYL]-BENZYL-1,2,4-TRIAZOLE;α，α，α’，α’-Tetramethyl-5-(1H-1，2，4-triazol-1-ylmethyl)-1，3-benzenediacetonitrile;2-[3-(2-Cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile;α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile;Anastrozole(AriMidex);Anastrozole (200 mg) |
| CAS NO: | 120511-73-1 |
| Molecular Weight: | 293.37 |
| Molecular Formula: | C17H19N5 |
| Boiling Point: | 469.7±55.0 °C(Predicted) |
| Melting point: | 81-82°C |
| Density: | 1.08±0.1 g/cm3(Predicted) |
| Appearance: | Pale Yellow Solid |
| Uses: | Anastrozole has significant effects on breast cancer treatment and, therefore, it is currently used as first-line treatment in estrogen receptor (ER)-positive postmenopausal women, particularly to treat locally advanced or metastatic breast cancer. Furthermore, it is also indicated for early cancer treatment, tumor chemoprevention and postmenopausal women using tamoxifen, especially if the drug is used during a prolonged period of time and has been indicated in the disease’s recurrence, i.e., as another therapeutic endocrine option. |
| Solubility: | DMSO: soluble40mg/mL |
| Storage: | room temp |
anastrozole side effects/side effects of anastrozole
- Blurred vision.
- bone pain.
- chest pain or discomfort.
- pounding in the ears.
- slow or fast heartbeat.
- swelling of the feet or lower legs.
anastrozole mechanism of action
Anastrozole works by reversibly binding to the aromatase enzyme, and through competitive inhibition blocks the conversion of androgens to estrogens in peripheral (extragonadal) tissues.The medication has been found to achieve 96.7% to 97.3% inhibition of aromatase at a dosage of 1 mg/day and 98.1% inhibition of aromatase at a dosage of 10 mg/day in humans. As such, 1 mg/day is considered to be the minimal dosage required to achieve maximal suppression of aromatase with anastrozole.This decrease in aromatase activity results in an at least 85% decrease in estradiol levels in postmenopausal women.Levels of corticosteroids and other adrenal steroids are unaffected by anastrozole.
anastrozole uses/what is anastrozole used for/What does anastrozole do?
Anastrozole has significant effects on breast cancer treatment and, therefore, it is currently used as first-line treatment in estrogen receptor (ER)-positive postmenopausal women, particularly to treat locally advanced or metastatic breast cancer. Furthermore, it is also indicated for early cancer treatment, tumor chemoprevention and postmenopausal women using tamoxifen, especially if the drug is used during a prolonged period of time and has been indicated in the disease’s recurrence, i.e., as another therapeutic endocrine option.
anastrozole for men
Increasing testosterone levels can help alleviate the issues associated with low testosterone, such as erectile dysfunction. As mentioned earlier, anastrozole may be prescribed to help increase testosterone levels in men.
anastrozole bodybuilding
Anastrozole 1 mg pills for sale work by inhibiting the enzyme aromatase, which converts testosterone into estrogen. Anastrozole can help bodybuilders avoid the unwanted side effects of excess estrogen by reducing the amount of estrogen in the body.
anastrozole side effects in females
- Nausea.
- Increased liver enzymes.
- Headaches.
- Hot flashes.
anastrozole vs letrozole/letrozole vs anastrozole
Anastrozole works by blocking aromatase enzyme, which is involved in estrogen production in the body. This leads to decreased tumor size or delayed progression of tumor growth in some women. Letrozole is an oral, anti-estrogen drug that is used for treating postmenopausal women with breast cancer.
anastrozole vs tamoxifen
Although both drugs have long been used as hormonal therapy in patients with breast cancer, they have different mechanisms of action. Tamoxifen is an antiestrogen agent, while anastrozole is an aromatase inhibitor.
foods to avoid when taking anastrozole
Avoid raw fruits, vegetables, whole-grain breads, cereals, and seeds. Soluble fiber is found in some foods and absorbs fluid, which can help relieve diarrhea.
anastrozole half life
The half-life of anastrozole is 50 hours, letrozole 48 hours, and exemestane 24 hours.
anastrozole dosage/anastrozole dose
The dose of Arimidex is one 1 mg tablet taken once a day. For patients with advanced breast cancer, the medication should be continued until tumor progression.
Additional information
| Color | White to offwhite |
|---|---|
| Form | Powder |
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