Tetracaine is a local anesthetic or numbing medicine that is used to numb the throat, eyes, or nose. Normally, the drug is administered before starting a surgery to decrease pain from the procedure. Tetracaine is applied to the eyes 30 minutes before the start of an intravenous and its effects can last up to 15 minutes.
- Additional information
Tetracaine CAS 94-24-6 Product Information
|Synonyms:||Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester;Tetracaina;Tetrakain;Anetain;EINECS 202-316-6;Pontocaine;Dicaine;Contralgin;2-(Dimethylamino)ethyl-4-(butylamino)benzolcarboxylat;Tetracainum;dicaine base;MFCD00053787;Amethocaine;2-(Dimethylamino)ethyl 4-(butylamino)benzoate;Uromucaesthin;Tetracaine|
|Boiling Point:||41.0 to 45.0 °C|
|Melting point:||41.0 to 45.0 °C|
|Density:||1.0200 (rough estimate)|
|Appearance:||White crystal powder|
|Applications:||Tetracaine is used in assessing the potential for drug-nanoparticle surface interactions to improve drug penetration into the skin.|
|Solubility:||156mg/L(temperature not stated) in water|
Tetracaine is an amino-ester class local anesthetic. It has been in use for a variety of purposes since the early 1930s, but its most common use today is as a topical ophthalmic anesthetic for short procedures on the surface of the eye, as well as the ears and nose. Spinal anesthesia is also another indication.
tetracaine mechanism of action
Tetracaine is an ester-type anesthetic and produces local anesthesia by blocking the sodium ion channels involved in the initiation and conduction of neuronal impulses. Tetracaine is rapidly hydrolyzed in the plasma; therefore, volume of distribution could not be determined.
Ophthalmic tetracaine is indicated for the for procedures requiring a rapid and short- acting topical ophthalmic anesthetic. The combination tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access.
Injectable solution 1 %
Powder for injection 20 mg
Ophthalmic solution 0.5 %
tetracaine spinal dose
High, medium, low & saddle: 0.2 %-0.3 % solution
For perineum: 5 mg/dose
For lower extremities: 10 mg/dose
For saddle block: 2-5 mg/dose
Prolonged (2-3 hours): 1 % solution
For spinal: 1 % solution diluted 1:1 in CSF, administered at 1 mL per 5 seconds
Doses of above 15 mg are rarely required, and should only be used in exceptional cases
Tetracaine is an ester local anesthetic with a high pKa of 8.5, slow onset, and long duration of action (60–360 minutes). It is among the most potent local anesthetics in clinical use today. It is also among the most toxic.
tetracaine side effects
- Blurred vision.
- redness of the clear part of the eye.
- sensitivity to light.
- severe stinging in the eye.
- throbbing eye pain.
There are no reviews yet.