Other MaterialsLocal AnestheticProcaine Hydrochloride CAS 51-05-8

SKU: WGP 51-05-8

Procaine Hydrochloride



Procaine hydrochloride, also called Novocain, or Novocaine, a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.

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Procaine Hydrochloride CAS 51-05-8 Product Description

Product Name: Procaine Hydrochloride
Synonyms: Procaine hcl crystal powder,Raw powder Procaine Hydrochloride price, cas 51-05-8, 51 05 8, Procaine hcl powder, Procaine Hydrochloride powder,Procaine Hydrochloride crystal powder, Procaine Hydrochloride factory,Procaine Hydrochloride manufacturer,procaine pwoder, procaine price, procaine crystal,procaine hcl crystaline,procaine crystal
CAS NO: 51-05-8
Molecular Weight: 272.77
Molecular Formula: C13H21ClN2O2
Boiling Point: 195-196°C/17mm
Melting point: 155-156 °C(lit.)
Density: 1.1761g/cm3
Appearance: white crystalline powder
Applications: Used as a topical anaesthetic and also used to control the pain of intramuscular injection of penicillin as well as in dentistry.
Solubility: Solution S is clear (2.2.1) and colourless (2.2.2, Method II).
Storage: Keep in unopened containers in a cool, dry and well ventilated place

procaine hydrochloride uses

Procaine Hydrochloride is a local anesthetic drug of the amino ester group.Target: OthersProcaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale.

synthesis of procaine hydrochloride/procaine hydrochloride synthesis

In there-necked flask, add p-nitrobenzoic acid 60g, dimethylbenzene 360g, Diethylaminoethanol 44g, reflux divides water, temperature of reaction 141 ~ 143 DEG C, reacts 12 hours; React complete, be cooled to less than 20 DEG C, reclaim under reduced pressure dimethylbenzene; Reclaim complete, be cooled to less than 40 DEG C, slowly drip 570g6% dilute hydrochloric acid, after adding, stir 30 minutes, be cooled to 20 ~ 25 DEG C, filter, obtain filtrate;
Upper step filtrate is added in hydrogenation reaction cauldron, add catalyst n i powder 15g, with nitrogen replacement 2 times, pass into hydrogen, pressure is 10 standard atmospheric pressures, control temperature of reaction 50 ~ 60 DEG C and carry out hydrogenation, react complete, filter, refined salt 16g is added in filtrate, stirring and dissolving, is cooled to 10 DEG C, obtains final product.



procaine hydrochloride side effects

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • chest pain or slow or irregular heartbeats;
  • dizziness or drowsiness;
  • anxiety or restlessness;
  • nausea or vomiting; or.
  • trembling, shaking, or seizures (convulsions).

procaine hydrochloride anti aging

Gerovital H3 (or procaine hydrochloride and products known as GH3 and other variants which may or may not be identical to Gerovital H3) is a preparation developed during the 1950s and promoted by its advocates as an effective anti-aging treatment.

procaine hydrochloride solubility

soluble in water, but less soluble in alcohol and almost insoluble in ether.


Additional information




Crystal powder

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