Sodium borohydride has a strong selective reduction, being able to selectively reduce a carbonyl group is to a hydroxyl group without reacting with the carbon-carbon double bond and triple bond reaction. A small amount of sodium borohydride can restore the nitrile to the aldehyde with the excess amount being reduced to the amine.
Sodium Borohydride CAS 16940-66-2 Product Information
|Product Name:||Sodium borohydride|
|Synonyms:||VenPure SF;SodiuM borohydride caplets (18 x 10 x 8 MM), 98%;SodiuM borohydride granular, 10-40 Mesh, 98%;SodiuM borohydride granular, 99.99% trace Metals basis;SodiuM borohydride powder, >=98.0%;SodiuM borohydride puruM p.a., >=96% (gas-voluMetric);SodiuM borohydride ReagentPlus(R), 99%;SodiuM borohydride solution 2.0 M in triethylene glycol diMethyl ether|
|Melting point:||>300 °C (dec.) (lit.)|
|Density:||1.035 g/mL at 25 °C|
|Stability:||Water Solubility 550 g/L (25 ºC)|
|Storage:||Store at RT.|
sodium borohydride reduction
Sodium borohydride (NaBH4) is a mild reducing agent that is typically used to reduce aldehydes and ketones to their respective alcohols. NaBH4 is sometimes used to reduce esters to alcohols but the reaction is generally slow.
sodium borohydride hazards
Breathing Sodium Borohydride can irritate the nose and throat. * Breathing Sodium Borohydride can irritate the lungs causing coughing and/or shortness of breath. Higher exposures can cause a build-up of fluid in the lungs (pulmonary edema), a medical emergency, with severe shortness of breath.
sodium borohydride sds/sodium borohydride msds
|RIDADR||UN 3129 4.3/PG 3|
|Autoignition Temperature||220 °C|
|Hazardous Substances Data||16940-66-2(Hazardous Substances Data)|
|Toxicity||LD50 orally in Rabbit: 160 mg/kg LD50 dermal Rabbit 230 mg/kg|
sodium borohydride reaction with water
At lower pH levels, sodium borohydride reacts exothermically with water to generate flammable hydrogen gas. The heat may ignite the hydrogen, the solvent, and surrounding combustible materials [Haz. Chem. Data 1966].
sodium borohydride uses
Sodium borohydride (NaBH4) is a versatile reducing agent used in a number of industrial processes. Major applications include organic and pharmaceutical synthesis, wastewater treatment, and paper pulp bleaching. Sodium borohydride plays such a significant role in organic synthesis. It is a good reducing agent which has stable performance and selective reduction. It can be used as the reducing agents of aldehydes, ketones and acid chlorides; also as foaming agent for plastic materials, hydrogenating agent of making dihydrostreptomycin, intermediate of making potassium borohydride, raw materials in synthesizing borane, as well as the treatment agent of paper industry and mercury-containing waste water.
sodium borohydride reaction with methanol
Reactions with Organic Compounds: Sodium borohydride reacts with methyl alcohol to produce sodium tetramethoxyborohydride and hydrogen ( 26).
sodium borohydride melting point
>300 °C (dec.) (lit.)
sodium borohydride boiling point
sodium borohydride density
sodium borohydride molar mass/sodium borohydride molecular weight
sodium borohydride solubility
soluble in alcohols, certain ethers, and water, although it slowly hydrolyzes