Pyrrolidine
CAS:123-75-1
MF:C4H9N
Pyrrolidine is a flammable alkaline liquid that undergoes reactions typical of secondary amines. It is used to prepare pesticides and rubber accelerators and as a chemical intermediate (usually the hydrochloride form) in the pharmaceutical industry.
- Description
- Additional information
Description
Pyrrolidine CAS 123-75-1 Product Information
Product Name: | Pyrrolidine |
Synonyms: | TETRAMETHYLENEIMINE;pyrrolidine,tetrahydropyrrole;PYRROLIDINE,REAGENT;TETRAHYDROPYRROLE (PYRROLIDINE);PYRROLIDINE 99+%;PYRROLIDINE, REDISTILLED, 99.5+%;1-AZACYCLOPENTANE;AKOS BBS-00003603 |
CAS NO: | 123-75-1 |
Molecular Weight: | 71.121 |
Molecular Formula: | C4H9N |
Boiling Point: | 89.5±8.0 °C at 760 mmHg |
Melting point: | -63 °C |
Density: | 0.8±0.1 g/cm3 |
Appearance: | Colorless transparent liquid |
Applications: | Pyrrolidine is a heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs). It has been used for the synthesis of N-benzoyl pyrrolidine from benzaldehyde via oxidative amination. It may be used as a catalyst for the synthesis of N-sulfinyl aldimines from carbonyl compounds and sulfonamides. |
Stability: | Stable; flammable. Incompatible with strong acids, strong oxidizing agents. |
Storage: | Store in an airtight seal away from light. Packed in galvanized iron drums. The warehouse is cool and ventilated, keep away from fire, fire source, sunscreen, acid and oxidant. |
pyrrolidine structure
Pyrrolidine is a cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family. It is a saturated organic heteromonocyclic parent, a member of pyrrolidines and an azacycloalkane. It is a conjugate base of a pyrrolidinium ion.
pyrrolidine synthesis
Laboratory synthesis
In the laboratory, pyrrolidine was usually synthesised by treating 4-chlorobutan-1-amine with a strong base:
Furthermore, 5-membered N-heterocyclic ring of the pyrrolidine derivatives can be synthesized via
pyrrolidine sds/pyrrolidine msds
Hazard Codes | F,T,C |
Risk Statements | 11-22-23-34-35-20/21/22-20/22-R35-R20/21/22-R11 |
Safety Statements | 16-26-36/37/39-45-33-S45-S36/37/39-S26-S16 |
RIDADR | UN 1922 3/PG 2 |
WGK Germany | 2 |
RTECS | UX9650000 |
F | 20 °C |
Autoignition Temperature | 34 |
TSCA | 653 °F |
HS Code | Yes |
HazardClass | 2933 99 80 |
PackingGroup | 3 |
pyrrolidine alkaloids
Pyrrolizidine alkaloids (PAs) are heterocyclic organic compounds synthesized by plants that are thought to act as defense compounds against herbivores [1]. Estimates indicate that approximately 6.000 plant species worldwide, representing 3% of all flowering plants, produce these secondary metabolites.
pyrrolidine pka
11.27(at 25℃)
pyrrolidine density/pyrrolidine density g/ml
0.8±0.1 g/cm3/0.852 g/mL at 25 °C (lit.)
pyrrolidine smell
Taste characteristics at 50 ppm: ammonia and fishy, amine-like with seaweed and shellfish nuances.
Additional information
Melting Point | -63 °C |
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Boiling point | 87-88 °C(lit.) |
Flash Point | 37 °F |
Density | 0.866 |
Color | Colorless |
Form | Liquid |
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