Tetramisole hydrochloride is an organic molecular entity. It is a broad-spectrum veterinary anthelmintic with high efficiency and low toxicity.
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Tetramisole Hydrochloride CAS 5086-74-8 Product Description
|Product Name:||Tetramisole Hydrochloride|
|Boiling Point:||344.4°C at 760 mmHg|
|Appearance:||White crystalline powder|
|Applications:||Tetramisole has been used to inhibit alkaline phosphatase in the effective range of 0.4 – 2 mM. Inhibition of intestinal alkaline phosphate requires higher concentrations. In addition to its use in enzyme and protein phosphorylation studies, tetramisole has been used to study membrane, tissue and animal systems.|
|Solubility:||easily soluble in water , Methanol, slightly soluble in ethanol, insoluble in acetone|
|Storage:||Keep in dark place,Inert atmosphere,Room temperature|
tetramisole hydrochloride uses
Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. It is suitable for inhibition of various alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor)(Intestinal alkaline phosphatases are only slightly inhibited.). Tetramisole has biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.
tetramisole hydrochloride solubility
Methanol (Slightly), Water (Slightly, Heated)
tetramisole hydrochloride synthesis
Firstly, heating and reacting styrene oxide and ethanol amine so as to obtain an addition product; secondly, adding an organic solvent and lewis acid into the addition product, controlling the reaction temperature and adding thionyl chloride so as to obtain a chlorination product; thirdly, adding deionized water into the chlorination product, dropping NaOH solution, subsequently dropping concentrated HCl and thiourea, heating and refluxing, cooling and separating a cyclization product; fourthly, mixing the cyclization product with concentrated HCl and lewis acid, adding NaOH solution so as to adjust the pH of the system, and heating and reacting so as to obtain a tetramisole product; and fifthly, adding deionized water into the tetramisole product, dropping concentrated HCl, and subsequently increasing the temperature and reacting so as to obtain tetramisole hydrochloride. According to the preparation method, tetramisole hydrochloride is synthesized by using a five-step method, the process is simple, the yield of each step can be more than 85%, and the yield is high.
tetramisole hydrochloride para que sirve
El tetramisol es una solución antiparasitaria interna de administración oral para perros cuya acción es la de un antiparasitario interno de amplio espectro que actúa sobre el sistema neuromuscular parasitario.
344.4ºC at 760 mmHg
200 g/L (20 ºC)
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