An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.Prilocaine is less toxic, with a high clearance, attributable to metabolism in the lungs, kidneys and liver.
- Additional information
Prilocaine CAS 721-50-6 Product Information
|Synonyms:||2-(Propylamino)-o-propionotoluidide; (±)-N-(2-Propylaminopropionyl)-2-toluidine; (±)-Prilocaine; 2-Methyl-α-propylaminopropionanilide; Astra 1512; Astra 1515; Citanest; DL-(±)-Prilocaine; N-(2,6-Dimethylphenyl)-2-(propylamino)propanamide; NSC 40027; Prilocaine; Propitocaine; o-Methyl-2-propylaminopropionanilide|
|Boiling Point:||bp0.1 159-162°|
|Density:||1.0117 (rough estimate)|
|Solubility:||Slightly soluble in water, very soluble in acetone and in ethanol (96 per cent).|
It is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.
prilocaine vs novocaine
Technically, the words “procaine” and “novocaine” are synonymous and may be used interchangeably. “Novocain” is a trade name for the generic drug procaine.
Prilocaine injection is used to numb the mouth before a dental procedure. This medicine is to be given by or under the direct supervision of your dentist.
prilocaine spinal dose/prilocaine dosage
infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours.
Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.
Epidural anesthesia: use10 to 30 mL of 1.5%~1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg.
prilocaine side effects
- Blurred vision.
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings in the lips or mouth.
- chest pain or discomfort.
- cold, clammy, pale skin.
- continuing ringing or buzzing or other unexplained noise in the ears.
- difficulty swallowing.
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