CompoundsActive IngredientsPolymyxin B CAS 1404-26-8

SKU: WGP-1404-26-8

Polymyxin B


Molecular Formula: C55H96N16O13

Molecular Weight: 1189.45


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Polymyxin B CAS 1404-26-8 Product Information

Product Name: Polymyxin B
Synonyms: polymyxin B 2.5sulfate entahydrate; Polymyxin B (base and/or unspecified salts); Polymyxin E see Colistin
CAS NO: 1404-26-8
Molecular Weight: 1189.45
Molecular Formula: C55H96N16O13
Boiling Point: 1572.3±65.0 °C at 760 mmHg
Density: 1.3±0.1 g/cm3
Appearance: White powder
Applications: Antibacterial Aerosporin.

What is Polymyxin B CAS 1404-26-8

Gram-negative bacterial infections are treated with polymyxin B, an antibiotic assigned the CAS number 1404-26-8. The main salient features of Polymyxin B are as follows:

1.Chemical structure and formula:

  • Mostly consisting of polymyxins B1 and B2, polymyxin B is a combination of similar molecules.
  • Its structure is cyclic peptide with extended hydrophobic tail.

2. Physical Characteristics:

  • polymyxin B is usually looking as a white to off-white powder
  • Solubility in water is high; in ethanol it is only marginally soluble.

3. Pharmalogical Characteristics:

  • Polymer B kills bacterial cells by upsetting their cell membrane.
  • Against Gram-negative bacteria especially include Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter species, it is especially successful.

4. Medical Purposes:

  • Polymyxin B treats localised infections of the skin, eyes, and ears by use of ointments, lotions, and eye/ear drops.
  • Severe systemic infections call for intravenous administration of the medication. For multidrug-resistant diseases, it’s sometimes used as a last-resort antibiotic.
  • Sometimes polymyxin B is combined with other antibiotics to improve its effectiveness and widen the spectrum of antibacterial action.

5. Administration and Dose:

  • The type and degree of the illness as well as the patient’s state determine the dosage and path of administration.
  • It is dabbed straight onto the afflicted area for topical application. For systemic infections, it is injected under medical expert supervision.

6. Safety, Side Effects:

  • Typical side effects from topically applied treatments could be redness, itching, or localised irritation. Systemic administration can produce nephrotoxicity (kidney damage) and neurotoxicity (nerve damage), which would show up as tingling or dizziness or weakness.
  • Seldom occurring but potentially fatal side effects include respiratory paralysis. Using Polymyxin B systemically calls for constant monitoring.
  • Patients with allergies to polymyxins, neuromuscular diseases, or previous kidney issues should exercise careful use of Polymyxin B. Dose changes can help to reduce the toxicity risk.

7. Managing and storing:

  • Stored in a cool, dry environment free from direct light and moisture, polymyxin B should Children should never be able to reach it.
  • Its stability and efficiency depend on correct handling in compliance with medical recommendations.

Polymyxin B is a strong antibiotic used generally to treat Gram-negative bacterial-caused illnesses. Particularly against multidrug-resistant strains, its efficacy makes it an important weapon in the fight against serious bacterial diseases. Management of possible adverse effects and guarantee of patient safety depend on correct administration and monitoring.


Transit time You will normally receive your parcel within 7-15 working days after shipment (this may be delayed in special circumstances, such as Chinese New Year).
Receiving method Generally we will send the goods by courier or special line, of course, if the goods themselves in the local warehouse have goods, also support self-pickup, depending on the circumstances.
Overseas warehouse We have overseas warehouses in some European countries and Australia, such as Germany, Russia and Australia.
Delivery Method WGP will ship via courier companies such as DHL, FedEx, UPS, TNT or EMS.
About After Sales Within 7 days of your receipt of the goods if you find any problems with the goods (broken packaging, less hair, etc.) please feel free to contact our sales, we will help you deal with it in time.

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