CompoundsActive IngredientsPolymyxin B CAS 1404-26-8

SKU: WGP-1404-26-8

Polymyxin B


MF: C55H96N16O13

Active against Gram-negative bacteria, Polymyxin B is a mixture of Polymyxin B1 and B2. Sensitization occurs by topical, ophthalmic, and otic preparations. Cosensitization is frequent with other topical antibiotics like neomycin or bacitracin.

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Polymyxin B CAS 1404-26-8 Product Information

Product Name: Polymyxin B
Synonyms: polymyxin B 2.5sulfate entahydrate; Polymyxin B (base and/or unspecified salts); Polymyxin E see Colistin
CAS NO: 1404-26-8
Molecular Weight: 1189.45
Molecular Formula: C55H96N16O13
Boiling Point: 1572.3±65.0 °C at 760 mmHg
Density: 1.3±0.1 g/cm3
Appearance: White powder
Applications: Antibacterial Aerosporin.

polymyxin b sulfate and trimethoprim ophthalmic solution uses/polymyxin b trimethoprim

Polymyxin B and trimethoprim ophthalmic combination is used to treat bacterial infections of the eye including conjunctivitis (pinkeye; infection of the membrane that covers the outside of the eyeball and the inside of the eyelid) or blepharoconjunctivitis (infection of the membrane that covers the outside of the eyeball and the inside and outer parts of the eyelid).

polymyxin b sulfate/polymyxin b sulphate

Polymyxin B (polymyxin b sulfate) sulfate is a drug of choice in the treatment of infections of the urinary tract, meninges, and bloodstream caused by susceptible strains of Ps. aeruginosa. It may also be used topically and subconjunctivally in the treatment of infections of the eye caused by susceptible strains of Ps. aeruginosa.

neomycin and polymyxin b sulfates/neomycin and polymyxin b

Neomycin and polymyxin B belong to the class of medicines known as antibiotics. They work by killing the bacteria or preventing their growth. Dexamethasone is a steroid medicine that is used to relieve the redness, itching, and swelling caused by eye infections.

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polymyxin b sulfate and trimethoprim doage

The combination of polymyxin B and trimethoprim comes as a solution (liquid) to instill in the eye. It is usually instilled once in the affected eye(s) every three hours (maximum of 6 doses in 24 hours) for 7 to 10 days.

polymyxin b dose

Systemic Infections

IV: 15,000-25,000 units/kg/day divided q12hr; not to exceed 25,000 units/kg/day
IM: 25,000-30,000 units/kg/day divided q4-6hr
Intrathecal: 50,000 qDay for 3-4 days; then qDay or qODay for at least 2 weeks after CSF cultures are negative and normal for glucose content
Total daily dose not to exceed 2,000,000 units/day

Renal Impairment

CrCl >20 mL/minute: give 75-100% usual dose/day divided q12hr
CrCl 5-20 mL/minute: give 50% usual dose/day divided q12hr
CrCl <5 mL/minute: give 15% usual dose/day q12hr

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polymyxin b side effects

  • Dizziness.
  • drowsiness.
  • headache.
  • numbness or tingling in hands or feet.
  • pain in the lower back or side.
  • shakiness and unsteady walk.
  • stiff neck.
  • unsteadiness, trembling, or other problems with muscle control or coordination.
polymyxin b mechanism of action

Polymyxins cause cell damage leading to cell death by disrupting the membrane integrity. This mechanism is also at play when the polymyxins interact with the membranes of the human cells, disintegrating them leading to toxicity.

neomycin and polymyxin b ear drops for ear infection/neomycin polymyxin b sulfates and hydrocortisone otic solution

Neomycin, polymyxin, and hydrocortisone otic combination is used to treat outer ear infections caused by certain bacteria. It is also used to treat outer ear infections that can occur after certain types of ear surgery. Neomycin and polymyxin are in a class of medications called antibiotics.


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