CompoundsActive IngredientsPantoprazole Sodium Cas NO.138786-67-1

SKU: WGP-138786-67-1

Cas 138786-67-1

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Product Name Pantoprazole Sodium
CAS NO 138786-67-1
Molecular Formula C16H14F2N3NaO4S
Molecular Weight 405.35

What is Pantoprazole Sodium?

Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white to off-white crystalline powder that is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane. The benzimidazole of this drug has weakly basic nitrogen (pyridine N, pKa 3.83) and a benzimidazole proton (pKa 0.11), facilitating formulation as the sodium salt. The stability of the compound in an aqueous solution’s pH-dependent; the rate of degradation increases with a decrease. At ambient temperature, the degradation half-life is approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (Cmax of2.5μg/mL, Tmax 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability). Administration with food may delay its absorption but does not alter pantoprazole bioavailability. Pantoprazole is distributed mainly in extracellular fluid. The serum protein binding of pantoprazole is about 98%, primarily to albumin. Pantoprazole has extensively metabolized in the liver through the CYP system, including O-demethylation (CYP2C19), with subsequent sulfation. Other metabolic pathways include sulfur oxidation by CYP3A4. There is no evidence that any of the pantoprazole metabolites have significant pharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excreted in the faeces through biliary excretion.

Packing material for different products: Aluminium foil bag, HDPE bottle, Iron drum, or according to require

Shelf Life:  2 Years from production date

Additional information

Weight 1 kg
Melting Point



White to offwhite




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