What is Pantoprazole Sodium?

Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white to off-white crystalline powder that is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane. The benzimidazole of this drug has weakly basic nitrogen (pyridine N, pKa 3.83) and a benzimidazole proton (pKa 0.11), facilitating formulation as the sodium salt. The stability of the compound in an aqueous solution’s pH-dependent; the rate of degradation increases with a decrease. At ambient temperature, the degradation half-life is approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (C_max of2.5μg/mL, T_max 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability). Administration with food may delay its absorption but does not alter pantoprazole bioavailability. Pantoprazole is distributed mainly in extracellular fluid. The serum protein binding of pantoprazole is about 98%, primarily to albumin. Pantoprazole has extensively metabolized in the liver through the CYP system, including O-demethylation (CYP2C19), with subsequent sulfation. Other metabolic pathways include sulfur oxidation by CYP3A4. There is no evidence that any of the pantoprazole metabolites have significant pharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excreted in the faeces through biliary excretion.

Packing material for different products: Aluminium foil bag, HDPE bottle, Iron drum, or according to require

Shelf Life:  2 Years from production date

Pantoprazole Sodium Product Parameter

Pantoprazole Sodium CAS138786-67-1 Usage

• Erosive Esophagitis: Pantoprazole is effective in treating erosive esophagitis, which is damage to the esophagus caused by stomach acid due to gastroesophageal reflux disease (GERD). It is prescribed for both adults and children aged 5 years and older.
• Zollinger-Ellison Syndrome: Pantoprazole is also used to manage Zollinger-Ellison syndrome, a rare condition characterized by excessive stomach acid production.
• Other Conditions: It can be helpful in other situations involving excess stomach acid.