Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline is an ergot derivative that may protect against degeneration of cholinergic neurones (Giardino et al.,2002). Nicergoline has a broad spectrum of action (Winblad et al,2008).
Nicergoline CAS 27848-84-6 Product Information
|Synonyms:||Ergobel;Nicergoline;Sermion;MNE;Cergodum;fi6714;nigergoline;3-Pyridinecarboxylic acid, 5-bromo-, [(8β)-10-methoxy-1,6-dimethylergolin-8-yl]methyl ester;Dilasenil;Cholergol;[(8β)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-bromonicotinate;Nargoline;5-Bromopyridine-3-carboxylic Acid [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl Ester;10-Methoxy-1,6-dimethylergoline-8β-methanol 5-bromonicotinate ester;TA 079;(8b)-10-Methoxy-1,6-dimethylergoline-8-methanol 5-Bromo-3-pyridinecarboxylate (Ester);4,6,6a,7,8,9,10,10a-Octahydro-10aa-metho;y-4,7-dimethylindolo[4,3-fg]quinoline-9-methanol 5-Bromonicotinate;5-bromo-nicotinic acid 10-methoxy-1,6-dimethyl-ergolin-8-ylmethyl ester;1-Methyllumilysergol 8-(5-Bromonicotinate) 10-Methyl Ether;ergoline-8-methanol 10-methoxy-1,6-dimethyl-,8-(5-bromo-3-pyridinecarboxylate);[(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-Bromopyridine-3-carboxylate;Nicergoline [USAN:BAN:INN:JAN]
|Boiling Point:||594.4±50.0 °C(Predicted)|
|Density:||1.3558 (rough estimate)|
|Appearance:||Fine to granular, white or yellowish powder|
|Storage:||Keep in dark place,Inert atmosphere,Store in freezer, under -20°C|
|Applications:||Nicergoline inhibits Alpha-1A adrenergic receptors.|
method for preparing nicergoline/chemical synthesis of nicergoline/How is nicergoline made?
Preparation of Nicergoline: To a solution of 1-methyl lumilysergol-10-methyl ether in pyridine, 5-bromonicotinyl chloride is used as an acylating agent at room temperature. The mixture is stirred for 1 hour. Water and methanol are added and the resulting mixture is stirred for 1 hour, extracted with chloroform, and washed in sequence with 1% aqueous caustic soda, 5% aqueous sodium bicarbonate solution, and water. The resulting solution is dried over anhydrous sodium sulfate and the solvent is distilled off. By recrystallization of the residue from acetone petroleum ether, nicergoline is obtained, melting at 136° to 138°C.
Forty six patients suffering from vertigo and tinnitus were treated with nicergoline in a dose of 15 mg/day for four or eight weeks. The efficacy of the drug in the reduction of vertigo was marked improvement in 11.1%, marked or moderate improvement in 62.5% and slight to marked improvement in 88.9% at four weeks.
Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.
nicergoline mechanism of action
Nicergoline acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
30 mg 1-2 times daily. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines. Should be taken on an empty stomach.
nicergoline and vinpocetine
Nicergoline + Vinpocetine is a combination of two medicines : Nicergoline and Vinpocetine. Nicergoline is a semi-synthetic ergoline derivative that induces vasodilation and increases arterial blood flow to the brain. This enhances neurotransmission function which improves brain activity. It also has antioxidant properties that help protect the damage to nerves from harmful toxins called free radicals. Vinpocetine is a nootropic alkaloid that acts as a neuroprotective agent that reduces damage to the brain from ischemia, stroke, and trauma. It also enhances the memory and increases brain metabolism.
nicergoline side effects
The side effects of nicergoline are usually limited to nausea, hot flushes, mild gastric upset, hypotension and dizziness. At high drug dosages, bradycardia, increased appetite, agitation, diarrhea and perspiration were reported.