CompoundsActive IngredientsGeneticin CAS 108321-42-2

SKU: WGP-108321-42-2



Molecular Formula: C20H42N4O14S

Molecular Weight: 594.63


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Geneticin CAS 108321-42-2 Product Information

Product Name: Geneticin
Synonyms: G418 disulfate;L-glycero-α-D-gluco-Heptopyranoside, (1R,2S,3S,4R,6S)-4,6-diamino-3-[[3-deoxy-4-C-methyl-3-(methylamino)-β-D-arabinopyranosyl]oxy]-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-, sulfate (1:2) (salt);G-418 sulfate;G 418 Sulfate,Cell Culture Tested;Antibiotic G418;(1S,2S,3R,4S,6R)-4,6-Diamino-3-({(5R)-2-amino-2-deoxy-5-[(1R)-1-hydroxyethyl]-α-D-xylopyranosyl}oxy)-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranoside sulfate (1:2)
G 418 Sulfate,Sterile-Filtered Aqueous Solution,Cell Culture Tested;Geneticin;D-glycero-α-D-gluco-Heptopyranoside, (1R,2S,3S,4R,6S)-4,6-diamino-3-[[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]oxy]-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-, sulfate (1:2) (salt);MFCD00058314;G418Sulfate/Geneticin;G-418 Disulphate;(1S,2S,3R,4S,6R)-4,6-Diamino-3-({(5R)-2-amino-2-deoxy-5-[(1S)-1-hydroxyethyl]-α-D-xylopyranosyl}oxy)-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-β-D-arabinopyranoside sulfate (1:2);G418 disulfate salt;G 418 disulfate salt;G418 Sulfate;Geneticin Disulfate Salt;G-418 (disulfate)
CAS NO: 108321-42-2
Molecular Weight: 594.63
Molecular Formula: C20H42N4O14S
Boiling Point: 1012.1ºC at 760mmHg
Appearance: white powder
Storage: Sealed storage, stored in a cool, dry warehouse. Refrigerate at 2-8ºC.
Applications: G-418 disulfate is an aminoglycoside antibiotic similar in structure to gentamicin B1, which can block the elongation phase of proteins during protein synthesis in prokaryotic and eukaryotic cells, thereby inhibiting protein synthesis.

What is Geneticin CAS 108321-42-2

Derived from Micromonospora rhodorangea, geneticin, sometimes known as G418, with a CAS number 108321-42, is an aminoglycoside antibiotic. As a selection agent for genetically modified cells expressing a resistance gene, it is extensively applied in molecular biology and cell biology. The following summarises the salient features of Geneticin:

1. Chemical Structure and Formula:

  • C20H40N4O10 is the geneticin chemical formula.
  • Comprising a core aminocyclitol connected to numerous sugar moieties, its structure is like that of other aminoglycosides.

2. Physical Attributes:

  • Appearance: Usually white to off-white, geneticin is a powder.
  • Solubility: At neutral pH it produces a stable solution; it is soluble in water.

3. Pharmacological Properties:

  • Geneticin reduces protein synthesis. It hooks to the 30S component of the ribosome, misreading mRNA and producing nonfunctional proteins in result.
  • It works well against both broad spectrum of prokaryotic and eukaryotic cells.

4. Applications in Molecular Biology:

  • In molecular biology, geneticin is mostly utilised as a selection agent in genetic engineering. While non-transformed cells are destroyed, transformed cells—those endowed with a vector expressing the neomycin resistance gene (neo) or kanamycin resistance gene (kanR)—can survive and multiply in the presence of Geneticin.
  • In mammalian, plant, and yeast cells, it is employed for maintenance and selection for stable transfections.
  • In biotechnological uses, Geneticin is chosen to select for cells expressing recombinant proteins.

5. Dosage and Usage:

  • The type of cell and experimental setting affects the effective concentration of Geneticin. For mammalian cells, usual values fall between 100 and 800 µg/mL; for bacterial cells, they fall between 10 and 400 µg/mL.
  • Before use, it is crucial to ascertain the minimum inhibitory concentration (MIC) for any particular cell line or organism.

6. Safety and Handling:

  • Geneticin can aggravate the skin, eyes, and respiratory tract following exposure, so posing health hazards. If taken orally or breathed, it could also be dangerous.
  • When working with Geneticin, suitable PPE including gloves, lab coats, and eye protection should be worn. Work should be done in a fume hood or well-ventilated space.
  • Storage: Geneticin ought to be kept dry, cold, free from light and moisture. Solutions should be kept stable by refrigerated at -20°C.

7. Local rules and guidelines should be followed while handling and disposing of geneticin to reduce environmental pollution. It shouldn’t be let into the surroundings unprocessed.

All things considered, Geneticin is a strong antibiotic applied widely in molecular and cell biology for the maintenance and selection of genetically altered cells. In biotechnological research and genetic engineering, its capacity to stop protein synthesis makes it an important instrument. Safe and efficient use of it depends on proper handling and safety precautions.

Transit time You will normally receive your parcel within 7-15 working days after shipment (this may be delayed in special circumstances, such as Chinese New Year).
Receiving method Generally we will send the goods by courier or special line, of course, if the goods themselves in the local warehouse have goods, also support self-pickup, depending on the circumstances.
Overseas warehouse We have overseas warehouses in some European countries and Australia, such as Germany, Russia and Australia.
Delivery Method WGP will ship via courier companies such as DHL, FedEx, UPS, TNT or EMS.
About After Sales Within 7 days of your receipt of the goods if you find any problems with the goods (broken packaging, less hair, etc.) please feel free to contact our sales, we will help you deal with it in time.

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