CompoundsActive IngredientsGeneticin CAS 108321-42-2

SKU: WGP-108321-42-2



MF: C20H42N4O14S

Geneticin (also known as G418, G418 sulfate) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells and is commonly used in laboratory research to select genetically engineered cells.

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Geneticin CAS 108321-42-2 Product Information

Product Name: Geneticin
Synonyms: G418 disulfate;L-glycero-α-D-gluco-Heptopyranoside, (1R,2S,3S,4R,6S)-4,6-diamino-3-[[3-deoxy-4-C-methyl-3-(methylamino)-β-D-arabinopyranosyl]oxy]-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-, sulfate (1:2) (salt);G-418 sulfate;G 418 Sulfate,Cell Culture Tested;Antibiotic G418;(1S,2S,3R,4S,6R)-4,6-Diamino-3-({(5R)-2-amino-2-deoxy-5-[(1R)-1-hydroxyethyl]-α-D-xylopyranosyl}oxy)-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranoside sulfate (1:2)
G 418 Sulfate,Sterile-Filtered Aqueous Solution,Cell Culture Tested;Geneticin;D-glycero-α-D-gluco-Heptopyranoside, (1R,2S,3S,4R,6S)-4,6-diamino-3-[[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]oxy]-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-, sulfate (1:2) (salt);MFCD00058314;G418Sulfate/Geneticin;G-418 Disulphate;(1S,2S,3R,4S,6R)-4,6-Diamino-3-({(5R)-2-amino-2-deoxy-5-[(1S)-1-hydroxyethyl]-α-D-xylopyranosyl}oxy)-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-β-D-arabinopyranoside sulfate (1:2);G418 disulfate salt;G 418 disulfate salt;G418 Sulfate;Geneticin Disulfate Salt;G-418 (disulfate)
CAS NO: 108321-42-2
Molecular Weight: 594.63
Molecular Formula: C20H42N4O14S
Boiling Point: 1012.1ºC at 760mmHg
Appearance: white powder
Storage: Sealed storage, stored in a cool, dry warehouse. Refrigerate at 2-8ºC.
Applications: G-418 disulfate is an aminoglycoside antibiotic similar in structure to gentamicin B1, which can block the elongation phase of proteins during protein synthesis in prokaryotic and eukaryotic cells, thereby inhibiting protein synthesis.

geneticin g418/g418 geneticin

G418 also known as G-418, G418 sulfate or Geneticin is an aminoglycoside antibiotic produced by Micromonospora rhodorangea.

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geneticin neomycin

Geneticin (aka G418 Sulfate) is a less toxic and very effective alternative for selection in mammalian cells. Neomycin can be used in bacterial selection, but Kanamycin is the preferred drug to use because of Neomycin’s toxicity.

geneticin vs gentamicin

Commonly known as G418 or G-418, Gibco Geneticin reagent is an aminoglycoside related to gentamicin and is commonly used as a selective agent for eukaryotic cells. As an analog of neomycin sulfate, it interferes with the function of 80S ribosomes and protein synthesis in eukaryotic cells.

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geneticin vs kanamycin

Kan is specific for prokaryotes, and geneticin is for eukaryotes, even though both antibiotics act in a similar way. If your plasmid encodes resistance for both, your bacteria will express kanr and not genr. The mammalian cells transfected with the same plasmid will express genr.

geneticin vs neomycin

Neomycin and G418 both will target cells which do not contain these genes and they will be eliminated. In general, neomycin is used in experiments on prokaryotic cells, while G418 is used in eukaryotic experiments.


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