Ergosterol
CAS:57-87-4
MF: C28H44O
Ergosterol may be used to study the function of anti-fungal drugs such as Amphotericin B and its analogues and to study the ergosterol biosynthesis pathway within various fungi. It acts as a useful indicator of living fungal biomass.Most important of the provitamins D. Usually obtained from yeast which synthesizes it from simple sugars such as glucose. Vitamin (antirachitic).
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Ergosterol CAS 57-87-4 Product Information
| Product Name: | Ergosterol |
| Synonyms: | Ergosterol;EINECS 200-352-7;(24R)-Ergosta-5,7,22-trien-3b-ol;(3S,9S,10R,13R,14R,17R)-17-[(2R,3E,5R)-5,6-Dimethyl-3-hepten-2-yl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;PROVIT;MIN D2;ERGOSTERINE;(22E)-Ergosta-5,7,22-trien-3β-ol;ERGOSTERIN;Ergosta-5,7,22-trien-3β-ol;PROVITAMINE D2;MFCD00003623;(3β)-Ergosta-5,7,22-trien-3-ol;(3b,22E)-Ergosta-5,7,22-trien-3-ol;Ergosta-5,7,22-trien-3-ol, (3β,22E)-;(3β,2E)-Ergosta-5,7,22-trien-3-ol;provitamind;(3β,22E)-Ergosta-5,7,22-trien-3-ol;Ergosta-5:6,7:8,22:23-trien-3-ol |
| CAS NO: | 57-87-4 |
| EINECS: | 200-352-7 |
| Molecular Formula: | C28H44O |
| Molecular Weight: | 396.66 |
| Melting point: | 156-158 °C(lit.) |
| Boiling point: | 250 °C (1.3 mmHg) |
| Density: | 0.9784 (rough estimate) |
| Appearance: | White to off-white Crystalline Powder or Crystalline Needles |
| Applications: | Ergosterol is the major sterol in fungi with antioxidant, antiproliferative and anti-inflammatory effects. |
ergosterol fungal
Ergosterol is a sterol found in cell membranes of fungi and protozoa, serving many of the same functions that cholesterol serves in animal cells. Because many fungi and protozoa cannot survive without ergosterol, the enzymes that synthesize it have become important targets for drug discovery1. Ergosterol is also an essential component of the fungal cell membrane and cellular levels of ergosterol directly affect various functions of the membrane2. It is involved in numerous biological functions such as membrane fluidity, regulation, activity and distribution of integral membrane proteins, and control of the cell cycle3. Ergosterol is also a provitamin form of vitamin D2; exposure to ultraviolet (UV) light causes a chemical reaction that produces vitamin D2
lanosterol to ergosterol
The general mechanism of action by which the azole antifungal family works is by inhibiting lanosterol 14-alpha-demethylase, which converts lanosterol to ergosterol in fungus cellular membranes. [7] The inability to produce ergosterol increases the membrane’s permeability, which results in cell lysis and death.
ergosterol and cholesterol
Ergosterol and cholesterol are two prominent sterols in eukaryotes. They are primarily lipid molecules. They also play vital roles in the survival of organisms. Ergosterol is the major sterol found in the plasma membrane of yeast and fungi, while cholesterol is the major sterol found in the plasma membrane of animals.
ergosterol function/ergosterol in fungi/what is ergosterol in fungi
Ergosterol, a 5,7-diene oxysterol, is the most abundant sterol in fungal cell membranes, where it regulates permeability and fluidity.Ergosterol biosynthesis is a complex and highly energy-consuming pathway that involves the participation of many enzymes.
ergosterol synthesis/ergosterol biosynthesis
Ergosterol biosynthesis is a complex and highly energy-consuming pathway that involves the participation of many enzymes. Deficiencies in sterol biosynthesis cause pleiotropic defects that limit cellular proliferation and adaptation to stress.
What is ergosterol?
Ergosterol (ergosta-5,7,22-trien-3β-ol) is a sterol found in cell membranes of fungi and protozoa, serving many of the same functions that cholesterol serves in animal cells.
ergosterol synthesis inhibitor
The ergosterol inhibitor class of medications (“conazoles”) is used to manage and treat fungal infections. These drugs inhibit ergosterol in the cell membrane to help kill fungi. This drug comes in both topical and systemic formulas.
ergosterol definition
A phytosterol consisting of ergostane having double bonds at the 5,6-, 7,8- and 22,23-positions as well as a 3beta-hydroxy group. A sterol occurring infungi, bacteria, algae, and plants.
ergosterol solubility
Acetone (Slightly, Heated), Chloroform (Slightly), Ethyl Acetate (Slightly, Heated),almost insoluble in water.
ergosterol vitamin d
In human nutrition, ergosterol is a provitamin form of vitamin D2; exposure to ultraviolet (UV) light causes a chemical reaction that produces vitamin D2.
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Additional information
| Color | White to offwhite |
|---|---|
| Form | Crystalline Powder or Crystalline Needles |
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