Clemastine Fumarate
CAS:14976-57-9
MF:C25H30ClNO5
Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM). It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling. Clemastine fumarate has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.
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Description
Clemastine Fumarate CAS 14976-57-9 Product Information
| Product Name: | Clemastine (fumarate) |
| Synonyms: | CLEMASTINE FUMARATE;CLEMASTINE FUMARATE SALT;(+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrro;(+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrroli;(+)-lfumarate(1:1);1-methyl-2-(2-(methyl-p-chlorodiphenylmethyloxy)ethyl)pyrrolidine;(2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE;2-(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine |
| CAS NO: | 14976-57-9 |
| Molecular Weight: | 459.96 |
| Molecular Formula: | C25H30ClNO5 |
| Boiling Point: | 154°C (rough estimate) |
| Melting point: | 158-162°C |
| Density: | 1.0247 (rough estimate) |
| Appearance: | white to beige powder |
| Applications: | Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM). It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling. Clemastine fumarate has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies. |
| Solubility: | DMSO: soluble5mg/mL (clear solution; warmed) |
| Storage: | 2-8°C |
clemastine fumarate and multiple sclerosis
Clemastine fumarate, an antihistamine medication, has gained attention in the context of multiple sclerosis (MS) due to its potential effects on myelin repair and disease progression. Myelin is the protective covering around nerve fibers that is damaged in MS.
In a small clinical trial published in 2017, researchers investigated the effects of clemastine fumarate on remyelination in patients with relapsing MS. The study found that participants who received clemastine fumarate showed improved visual evoked potentials, which are indicators of myelin repair and nerve conduction.
These findings were encouraging, as remyelination is a key aspect of potentially slowing or reversing disease progression in MS. However, it’s important to note that more research is needed to confirm and further understand the potential benefits of clemastine fumarate in MS treatment.
If you have MS or are considering treatment options, it is crucial to consult with a healthcare professional who specializes in MS or a neurologist. They can provide personalized advice based on your specific circumstances and help determine the most appropriate treatment options for you. They will consider factors such as the severity and type of MS, your overall health, and the latest research and clinical guidelines.
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clemastine fumarate ms
Clemastine fumarate, an antihistamine medication, has been investigated for its potential effects on multiple sclerosis (MS) in some research studies. These studies have explored its potential role in promoting remyelination, which is the repair of the protective covering around nerve fibers that is damaged in MS.
One notable study, published in 2017, examined the effects of clemastine fumarate on remyelination in patients with relapsing MS. The study found that participants who received clemastine fumarate showed improved visual evoked potentials, which are indicators of myelin repair and nerve conduction.
Additional information
| Weight | 1 kg |
|---|---|
| Melting Point | 177-180°C |
| Solubility | DMF: 1.6 mg/ml |
| Color | White |
| Form | Powder |
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