CompoundsActive IngredientsClotrimazole CAS 23593-75-1

SKU: WGP-23593-75-1-1



Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and, like other imidazoles, disturbs the fungal cell membrane.

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  • Additional information


Clotrimazole CAS 23593-75-1 Product Information

Product Name: Clotrimazole
Synonyms:  component of Otomax;Empecid;FB 5097;fb5097;Gyne lotrimin;Imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-;Methane, bis-phenyl-(2-chlorophenyl)-1-imidazolyl-;Mono-baycuten
CAS NO: 23593-75-1
Molecular Weight: 344.837
Molecular Formula: C22H17ClN2
Boiling Point: 482.3±40.0 °C at 760 mmHg
Melting point: 147-149ºC
Density: 1.1±0.1 g/cm3
Appearance: White to Almost white crystalline powder
Applications: An antifungal compound and CYP inhibitor.
Clotrimazole (Lotrimin, Mycelex, etc.) is a synthetic imidazole agent. It acts by altering cell membrane permeability. It inhibits the growth of most dermatophyte species, yeast and Malassezia furfur.
Solubility: Soluble in chloroform, DMSO, DMF and alcohols
Storage: 2-8°C

clotrimazole cream uses

Clotrimazole cream is an antifungal medication that is commonly used to treat various fungal infections of the skin. It belongs to the imidazole class of antifungal drugs and works by inhibiting the growth of fungi.

Here are some common uses of clotrimazole cream:

  1. Athlete’s foot (Tinea pedis): This is a fungal infection that affects the feet, causing itching, redness, and flaking of the skin between the toes and on the soles.
  2. Jock itch (Tinea cruris): It is a fungal infection that typically affects the groin area, causing a red, itchy rash.
  3. Ringworm (Tinea corporis): Ringworm is a skin infection characterized by circular or ring-shaped patches with red edges and a clear center. Clotrimazole cream can help alleviate the symptoms and treat the infection.
  4. Candidiasis: Clotrimazole cream can also be used to treat yeast infections caused by Candida species, such as vaginal yeast infections (vulvovaginal candidiasis) and yeast diaper rash in infants.

When using clotrimazole cream, it is important to follow the instructions provided by your healthcare professional or the product packaging. Apply a thin layer of the cream to the affected area and gently rub it in. It is typically applied 2-3 times a day for a specified duration, which can vary depending on the specific condition being treated.

butenafine hydrochloride vs clotrimazole

Butenafine hydrochloride and clotrimazole are both antifungal medications used to treat various fungal infections of the skin. While they have a similar purpose, there are differences in their mechanisms of action and specific uses.

Butenafine hydrochloride:

  • Butenafine is an antifungal medication that belongs to the allylamine class of drugs.
  • It works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes, which leads to the disruption of fungal growth and ultimately kills the fungus.
  • Butenafine is commonly used to treat athlete’s foot (Tinea pedis), jock itch (Tinea cruris), and ringworm (Tinea corporis).


  • Clotrimazole is an antifungal agent that belongs to the imidazole class of drugs.
  • It works by interfering with the synthesis of ergosterol, which disrupts the integrity of the fungal cell membrane and results in the death of the fungus.
  • Clotrimazole is used to treat a variety of fungal infections, including athlete’s foot, jock itch, ringworm, vaginal yeast infections (vulvovaginal candidiasis), and yeast diaper rash.

Both butenafine hydrochloride and clotrimazole are available in various formulations, including creams, sprays, and powders, for topical application to the affected areas of the skin. The choice between the two medications may depend on factors such as the specific type and severity of the fungal infection, individual response to treatment, and personal preferences.

clotrimazole and betamethasone dipropionate cream

Clotrimazole and betamethasone topical combination is used to treat fungus infections. Clotrimazole works by killing the fungus or preventing its growth. Betamethasone, a corticosteroid (cortisone-like medicine or steroid), is used to help relieve redness, swelling, itching, and other discomfort of fungus infections.

miconazole vs clotrimazole

The key difference between clotrimazole and miconazole is that clotrimazole usually shows a slow response against dermatophytosis and a faster response against candidiasis, whereas miconazole shows an accelerated response against dermatophytosis and a slow response against candidiasis.

tolnaftate vs clotrimazole

Clotrimazole cream treatment is more effective than tolnaftate for uncomplicated otomycosis.

Additional information

Weight 1 kg
Melting Point


Boiling point 

482.3±40.0 °C at 760 mmHg

Flash Point

245.5±27.3 °C


1.1±0.1 g/cm3


Soluble in chloroform, DMSO, DMF and alcohols,insoluble in water





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