Clotrimazole
CAS:23593-75-1
MF:C22H17ClN2
Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and, like other imidazoles, disturbs the fungal cell membrane.
- Description
- Additional information
Description
Clotrimazole CAS 23593-75-1 Product Information
| Product Name: | Clotrimazole |
| Synonyms: | component of Otomax;Empecid;FB 5097;fb5097;Gyne lotrimin;Imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-;Methane, bis-phenyl-(2-chlorophenyl)-1-imidazolyl-;Mono-baycuten |
| CAS NO: | 23593-75-1 |
| Molecular Weight: | 344.837 |
| Molecular Formula: | C22H17ClN2 |
| Boiling Point: | 482.3±40.0 °C at 760 mmHg |
| Melting point: | 147-149ºC |
| Density: | 1.1±0.1 g/cm3 |
| Appearance: | White to Almost white crystalline powder |
| Applications: | An antifungal compound and CYP inhibitor. Clotrimazole (Lotrimin, Mycelex, etc.) is a synthetic imidazole agent. It acts by altering cell membrane permeability. It inhibits the growth of most dermatophyte species, yeast and Malassezia furfur. |
| Solubility: | Soluble in chloroform, DMSO, DMF and alcohols |
| Storage: | 2-8°C |
What is clotrimazole used for?
Clotrimazole is an antifungal medicine. It’s used to treat skin infections caused by a fungus (yeast). It works by killing the fungus that is causing the infection.
How long does clotrimazole take to work on thrush?
Clotrimazole lozenge is absorbed by the body and begins to treat oral thrush within 30 to 60 minutes after taking your dose. Most people will begin to feel relief in about a week, but it takes 2 weeks to completely get rid of the fungus causing your infection.
clotrimazole and betamethasone
Clotrimazole and betamethasone topical combination is used to treat fungus infections. Clotrimazole works by killing the fungus or preventing its growth. Betamethasone, a corticosteroid (cortisone-like medicine or steroid), is used to help relieve redness, swelling, itching, and other discomfort of fungus infections.
clotrimazole solution for ear
Spread clotrimazole solution thinly and evenly on the affected areas. A few drops of clotrimazole solution should be enough to cover an area the size of a hand. If it’s your ear that’s infected, put 2 to 3 drops of clotrimazole solution into your ear.
clotrimazole on face
This medicine is for use on the skin only. Do not get it into your eyes, nose, mouth, or vagina, or apply it on your face or under your arms.
miconazole vs clotrimazole/miconazole or clotrimazole
The key difference between clotrimazole and miconazole is that clotrimazole usually shows a slow response against dermatophytosis and a faster response against candidiasis, whereas miconazole shows an accelerated response against dermatophytosis and a slow response against candidiasis.
ketoconazole vs clotrimazole/clotrimazole vs ketoconazole
Lotrimin AF (clotrimazole) is an effective over-the-counter medication used for athlete’s foot, ringworm, and jock itch, but it shouldn’t be used for more serious infections. Ketoconazole cream can help treat several different types of fungal skin infections. It’s applied onto the skin and has very few side effects.
tolnaftate vs clotrimazole
Clotrimazole cream treatment is more effective than tolnaftate for uncomplicated otomycosis.
betamethasone / clotrimazole side effects
- Blistering, burning, itching, peeling, dryness, redness, or other signs of skin irritation not present before use of this medicine.
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings.
Additional information
| Weight | 1 kg |
|---|---|
| Melting Point | 147-149°C |
| Boiling point | 482.3±40.0 °C at 760 mmHg |
| Flash Point | 245.5±27.3 °C |
| Density | 1.1±0.1 g/cm3 |
| Solubility | Soluble in chloroform, DMSO, DMF and alcohols,insoluble in water |
| Color | White |
| Form | Powder |
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