CompoundsActive IngredientsEfinaconazole CAS 164650-44-6

SKU: WGP-164650-44-6

Efinaconazole

CAS:164650-44-6

MF:C18H22F2N4O

In October 2013, efinaconazole (also known as KP-103) was approved in Canada as a 10% topical solution for the treatment of onychomycosis. Like other azole antifungal agents, efinaconazole acts by disrupting fungal cell membranes through inhibition of sterol 14α-demethylase, an enzyme involved in the biosynthesis of ergosterol, which is a key component of the fungal cell membrane.  Unlike other antifungal agents, efinaconazole retains activity in the presence of keratin, indicating that more unbound drug is available at the site of action.

  • Description
  • Additional information

Description

Efinaconazole CAS 164650-44-6 Product Information

Product Name:Efinaconazole
Synonyms:KP 103;KP 103 (pharmaceutical);(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol;Efinaconazole(KP 103);(R,R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol;(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol;1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-;Efinaconazole (Jublia)
CAS NO:164650-44-6
Molecular Weight:348.390
Molecular Formula:C18H22F2N4O
Boiling Point:512.2±60.0 °C at 760 mmHg
Melting point:192-195°C
Density:1.26±0.1 g/cm3(Predicted)
Appearance:white to beige powder
Applications:Efinaconazole is a broad-spectrum triazole antifungal agent with activity against Acremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton, and Trichosporon.
Solubility: Chloroform (Slightly), Methanol (Slightly)
Storage:-20°C

Customized packaging on demand

What is Efinaconazole?

Efinaconazole is a broad-spectrum triazole antifungal agent with activity against Acremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton, and Trichosporon. It inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and of C. Albicans isolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane. It inhibits ergosterol biosynthesis in T. mentagrophytes and C. Albicans with IC50 values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.

efinaconazole efficacy/efinaconazole how well does it work

It inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and of C. albicans isolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol biosynthesis at the fungal membrane. It inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with IC50 values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.Our factory and lab

efinaconazole vs tavaborole/tavaborole vs efinaconazole/efinaconazole vs ciclopirox

Efinaconazole showed potent fungicidal activity in keratin-containing medium, whereas tavaborole was fungistatic, and ciclopirox not active. In the guinea pig model of onychomycosis, the therapeutic efficacy of efinaconazole was superior to those of tavaborole and ciclopirox.transportation

 

Additional information

Melting Point

156°C

Boiling point 

600.0±60.0 °C(Predicted)

Flash Point

9 °C

Density

1.332 g/cm3

Solubility 

H2O: 0.5 mg/mL

Color

White

Form

Powder

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