Cas 28578-16-7 PMK Ethyl Glycidate: substitute for 13605 gradually

What is PMK ethyl glycidate(Cas 28578-16-7)?

PMK ethyl glycinate (Cas 28578-16-7) is an analytical reference standard categorized as a precursor in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA. This product is intended for research and forensic applications.

There are two specifications: PMK methyl Glycidate powder Cas 13605-48-6, PMK ethyl Glycidate oil Cas 28578-16-7.

A short history of PMK glycinate and PMK glycidic

PMK glycinate and PMK glycidic acid are used in and are important to the manufacture of the schedule I controlled substance 3,4-methylenedioxymethamphetamine (MDMA) and other “ecstasy”-types substances.

APAA is used in and is important to the manufacture of the schedule II controlled substances amphetamine and methamphetamine. If finalized, this action would subject handlers (manufacturers, distributors, importers, and exporters) of PMK glycinate, PMK glycidic acid, and APAA to the chemical regulatory provisions of the CSA and its implementation regulations. This action does not propose the establishment of a threshold for domestic and international transactions of these chemicals.

As such, all transactions involving any of these chemicals, regardless of size, would be regulated.

In addition, this action proposes that chemical mixtures containing any of these three chemicals would not be exempt from regulatory requirements at any concentration.

Therefore, all transactions of chemical mixtures containing any quantity of PMK glycinate, PMK glycidic acid, or APAA would be regulated.

PMK ethyl glycidate(Cas 28578-16-7)

What are the Chemical Mixtures of PMK Glycidate, and PMK Glycidic Acid?

Under this final rulemaking, chemical mixtures containing any of these three chemicals are subject to regulatory requirements at any concentration unless a manufacturer submits to DEA an application for exemption of a chemical mixture, DEA accepts the application for filing, and DEA exempts the chemical mixture by 21 CFR 1310.13.

Since even a small amount of these three chemicals can potentially yield a significant amount of controlled substances, DEA believes that regulation of chemical mixtures containing any amount of these three chemicals is necessary to prevent their illicit extraction, isolation, and use.

This rule modifies the “Table of Concentration Limits” in 21 CFR 1310.12(c) to reflect the fact that chemical mixtures containing any amount of these three chemicals are subject to CSA chemical control provisions, including 21 CFR parts 1309, 1310, 1313, and 1316.

PMK Glycidate markets — production and supply pre-precursor market and the clandestine production of amphetamine-type stimulants (ATS) have become more diverse in recent years.  This conclusion is based on seizure data from police and customs. However, analytical data are needed to confirm and quantify the actual prevalence of new pre-precursors by elucidating the percentage of seized ATS that have been produced from them.

A recent study showed that APAAN use is declining, which supports the view that new pre-precursors are being used. In this study, several conversion procedures using different batches of glycidic acid derivatives and a complete Leuckart reaction to produce amphetamine were carried out. The resulting organic phases were analyzed using gas chromatography-mass spectrometry to identify possible marker compounds.

Three marker compounds were discovered and characterized using mass spectra and nuclear magnetic resonance spectroscopy. They were identified as phenyl-1-propanone, N-(1-phenyl propyl)formamide, and 1-phenyl propane-1-amine. Their prevalence was investigated by searching the markers in an amphetamine impurity profiling database to determine to what extent they occurred in amphetamine samples from recent years.

Data from the central German amphetamine profiling database of more than 250 cases were used for this purpose. The yearly occurrence of the three glycinate marker compounds was determined going back as far as 2009, revealing an increasing trend from 2016 on. This article presents experimental proof that APAAN is currently being replaced by other pre-precursors, such as glycidic acid derivatives.

How do you make benzyl methyl ketone?

Methyl benzyl ketone has been prepared by distilling a mixture of the barium1 or calcium2 salts of phenylacetic and acetic acids. Bypassing the vapours of these acids over a heated thorium oxide catalyst; 3, 4 and by heating phenylacetic acid, sodium acetate, and acetic anhydride.

PMK, As stated above, the only use for PMK glycinate and PMK glycidic acid is as intermediaries for the manufacturing of MDMA and other “ecstasy”-type substances. Similarly, the only use for APAA is as a precursor for amphetamine and methamphetamine

What is the PMK chemical used for?

PMK glycinate and PMK glycidic acid are used in and are important to the manufacture of the schedule I controlled substance 3,4-methylenedioxymethamphetamine (MDMA) and other “ecstasy”-type substances

 

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