Sesamol Mechanism Of Action and Main Function

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1.What is sesamol?



Sesamol, together with its conjugated metabolites, is distributed in body tissues like liver, brain, lungs as well as the kidneys.

When Sesamol is absorbed in the body, it protects DNA from damages and enhances DNA repair to rectify aftery-radiation damage.

Because of its varied vivo bioactivities, sesamol plays an important role in the treatment of various diseases. One study established that sesamol inhibits the HepG2 cell colony formation. This supports other studies that suggest that Sesamol powder (533-31-3) ruins the viability of the cancer cells.Normally, the majority of cancer cells need more oxidative stress as compared to the healthy cells in order to maintain the proliferation-apoptosis balance.

Some studies indicate that the interaction of sesamol and DNA is likely to take place at the latter s groove. Still on that, another research study shows that the cell cycle that has been induced by sesamol arrest at S phase, and this happens in a concentration-dependent way. This is how sesamol causes DNA damage and obstructs the replication of DNA.




2.Sesamol General Description


Sesamol is a natural organic compound which is a component of sesame oil. Sesamol has been found to be an antioxidant that may prevent the spoilage of oils, and may protect the body from damage from free radicals. It also may prevent the spoilage of oils by acting as an antifungal. Sesame oil is used in Ayurvedic medicine and sesamol may play a key role in this traditional field. Sesamol possesses a number of pharmacological properties which include anti-inflammatory, antioxidant, and neuroprotective properties. Sesamol pretreatment offers radioprotection and prevents radiation induced chromosomal aberrations in human blood lymphocytes.

Sesamol powder is crop that is grown for the oil in its seed. It is found in tropical and subtropical areas of Asia, Africa, and South America. Compared to similar crops, such as peanuts, soybean, and rapeseed, the seeds of sesame are believed to have the most oil. Sesame seeds are also rich sources of protein, vitamins, and antioxidants.

People take sesame by mouth for Alzheimer s disease, anemia, arthritis, heartdisease prevention, cataracts, constipation, high cholesterol, infertility in men, menopause, osteoporosis, pain, stomach ulcers, stomach cancer, stroke, and weight loss.

People apply sesame oil to the skin for aging skin, hair loss, anxiety, frostbite,psoriasis, warts, wound healing, pain, and to prevent bug bites.

People use sesame oil injections to improve the vocal cords.

In foods, sesame oil is used as cooking oil and to make dressings and sauces.Sesame seeds are added to food for flavoring.



3.Sesamol Mechanism Of Action and Main Function


Sesamol contains chemicals that help to reduce swelling and increase how quickly skin wounds heal. These chemicals might slow how fast sugar is absorbed from food. This might help people with diabetes. Sesame might also eliminate bacteria that cause plaque. Sesame contains calcium, which might help treat rickets.



Sesamol Main Function


1.Sesamol has effect on improving the lipid profile;

2.Sesamol has function of normalizing the blood pressure;

3.Sesamol can be used for loss weight;

4.Sesamol can increase ketone production;

5.Sesamol also has function of anti-inflammatory.Sesamin has effect on antiviral, fungicides, antioxidants, insecticide synergist.

6.Sesamol can also be used to the treatment of bronchitis.

7.Sesamol has the function of inhibition the influenza virus, Sendai virus and Mycobacterium tuberculosis.





4.Sesamol benefits for neuroprotection


The major benefit of sesamol is Neuroprotection and here s how it offers that:


  1. Brain insulin signaling pathway regulation


Sesamol plays a significant role in the regulation of insulin signaling pathway in the brain. The antioxidant activated the IRS-1/AKT molecular pathway, and this makes the body to respond more quickly to insulin level changes.

In addition to making your body more sensitive to insulin fluctuations, sesamol promotes the metabolism of brain energy as well as the brain cells. It minimizes the levels of blood glucose levels and boosts  Streptozotocin (STZ) , which are primarily meant to deter the functionality of the beta cells that are responsible for the production of insulin in the pancreas.



  1. Neurodegenerative disease regulation


The oxidating compound achieves that by boosting the brain s oxidative stress. This reduces the production and release of the substances that might result in cancer-causing inflammations. Besides, the functionality of the barrier between the blood and the brain is improved.

As a result, a person s susceptibility to brain conditions such as Alzheimer s disease and neurodegenerative lesions is minimized. This also means that a person who already has brain structural abnormalities as a result of old age or Alzheimer s disease, among other brain-related issues can experience a relief of the related symptoms should they use sesamol as recommended.

Research shows that sesamol increases acetylcholine transferase (ChAT) activity as well as Acetylcholine (Ach) levels. Ach is among vital central cholinergic system neurotransmitters.



At the same time, the oxidant reduces the activity of cholinesterase (AchE). As such, researchers have established that sesamol has a positive effect on the learning as well as the memory function in humans.





Reference

  1. Sesamol Archived 2010-01-14 at the Wayback Machine at Chemicalland21.com


  2. Joo Yeon Kim, Dong Seong Choi and Mun Yhung Jung "Antiphoto-oxidative Activity of Sesamol in Methylene Blue- and Chlorophyll-Sensitized Photo-oxidation of Oil" J. Agric. Food Chem., 51 (11), 3460 -3465, 2003.


  3. Ohsawa, Toshiko. "Sesamol and sesaminol as antioxidants." New Food Industry (1991), 33(6), 1-5.


  4. Wynn, James P.; Kendrick, Andrew; Ratledge, Colin. "Sesamol as an inhibitor of growth and lipid metabolism in Mucor circinelloides via its action on malic enzyme." Lipids (1997), 32(6), 605-610.


  5. A Closer Look at Ayurvedic Medicine". Focus on Complementary and Alternative Medicine. Bethesda, Maryland: National Center for Complementary and Alternative Medicine (NCCAM), US National Institutes of Health (NIH). 12 (4). Fall 2005 C Winter 2006. Archived from the original on 2006-12-09.


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