Fat Killer--Cetilistat VS Orlistat

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1. What is Cetilistat?


Cetilistat (CAS no.282526-98-1) also known as ATL-962, ATL 962 or Citilistat is a drug indicated for the treatment of obesity. It is used along a low calorie, low-fat diet, and proper exercise to aid in weight loss.

The cetilistat anti-obesity drug is sold under different brand names including Cetislim,  Kilfat, Oblean, and Checkwt.

Cetilistat is a benzoxazine, gastrointestinal lipase inhibitor that primarily works by preventing the digestion and absorption of dietary fats.



2. How Cetilistat treats obesity?


Obesity is one of the most prevalent public health problems in the world today. It is a complex, chronic as well as a multifactor disorder characterized by the accumulation of excess fat/adipose tissue.

Obesity is associated with health disorders such as type 2 diabetes, hypertension, hyperlipidemia, high cholesterol, certain cancers, and some cardiovascular disease such as stroke and coronary heart disorder.

Obesity in many countries has reached epidemic proportions and hence a worldwide health concern.

Research shows that a sustained weight loss of 5 to 10 % of your initial body weight can significantly reduce obesity-related metabolic disorders.

Cetilistat is considered an anti-obesity agent. Anti-obesity agents usually increase energy expenditure thus weight loss through both neural and metabolic regulation.

Cetilistat is a gastrointestinal pancreatic lipase inhibitor that is an effective anti-obesity agent in human studies.

Cetilistat works by blocking the digestion and absorption of fat within the food you consume. When the fat is not digested it is excreted in feces during bowel movements. It accomplishes this by inhibiting the enzyme lipases responsible for breaking down triglycerides (a fat/lipid in the body) in the intestines.

The cetilistat effects are therefore exhibited in the gastrointestinal tract. It hence means that cetilistat is distinct from other anti-obesity agents that influence your brain to reduce appetite because it works periphery.

When the digestion and absorption of dietary fats are inhibited, deposition of fats is limited thus low energy expenditure that results in weight loss.

Although, Cetilistat will help you lose weight it is upon you to maintain a low-fat nutritious diet accompanied by exercise for successful obesity management.


3. Cetilistat VS Orlistat


Both cetilistat and orlistat are prescription drugs used for the treatment of obesity. They exhibit a similar mode of action through which they achieve weight loss.

Cetilistat and orlistat are gastrointestinal lipases inhibitor that prevents or reduces the digestion and absorption of dietary fats. The lipases are responsible for the breakdown of triglycerides in the intestines. The unchanged fats are instead excreted through bowel movements in human feces. This activity ensures that the fats are not absorbed in the body leading to weight loss.

Significant weight reduction has been reported in both cetilistat and orlistat. The success of cetilistat vs orlistat depends on your lifestyle as they require you to stick to a low-calorie nutritious diet coupled with regular exercise.

Cetilistat as well as orlistat exhibit enhanced glycemic control as evidenced by a significant reduction in plasma glycosylated hemoglobin. They also reduce the risk of obesity-related disorders such as heart diseases, high blood pressure, high cholesterol levels, and type 2 diabetes.

The most common side effects associated with cetilistat and orlistat are gastrointestinal effects usually due to the unchanged fats. However, when you compare cetilistat vs orlistat in terms of side effects, more side effects are associated with orlistat than in cetilistat. In addition, the severity of the effects is more pronounced with orlistat than with cetilistat.

When comparing the tolerability of cetilistat vs orlistat, cetilistat has been reported to be well tolerated than orlistat.


A 12 weeks study involving obese patients with type 2 diabetes was conducted to assess weight loss, reduction in glycosylated hemoglobin, and tolerability of cetilistat compared to orlistat. The treatment was combined with a low to moderate fat diet and diabetes mellitus managed using metformin.

The study found that both cetilistat and orlistat significantly reduced weight as well as improved glycemic control. The drugs also reduced the risk of cardiovascular disorders by reducing waist circumference which is an indicator of heart disease.

In this study, the side effects observed were gastrointestinal effects which were more with orlistat, and also the severity of orlistat-related effects was found to be higher than that of cetilistat. The differences in the effects of cetilistat vs orlistat may be attributed to their structural and chemical differences.

Withdrawals from the study were due to side effects and were more with orlistat than with cetilistat. Furthermore, cetilistat was more tolerated than orlistat.


4. Who can use Cetilistat?


You may consider taking Cetilistat (282526-98-1) if you need to lose weight. However, like with any other drug, take the necessary precautions while taking this medication.

Cetilistat is recommended for persons with a body mass index (BMI) that is higher than 27. It is also advisable to take cetilistat if your BMI is higher than 27 and you suffer from conditions associated with obesity such as diabetes and hypertension. BMI is an indicator of body fat calculated by dividing your weight in kilograms by the square of height in meters.

If you chose to take cetilistat, be sure to take the recommended cetilistat dosage with your meals. The prescribed cetilistat dosage is best taken with meals, during or up to one hour after your meals.

The cetilistat drug occurs in capsules or tablet form for oral administration with a glass of water.  You may also find cetilistat powder. The right cetilistat dosage and duration of treatment will be determined by your healthcare provider based on the condition and initial response to the medication.

Cetilistat weight loss benefits are however not indicated for children, hence you should not give this to children. This is especially with children in puberty as cetilistat might influence their growth more so with height.

Cetilistat is considered unsafe for pregnant mothers or women trying to conceive. It can pose a health risk to the unborn child.

Breastfeeding mothers are also advised to avoid cetilistat as it could pass through to the child.

Your doctor may advise you to take or otherwise avoid cetilistat due to other prevailing health conditions such as hypersensitivity, cholestasis (liver disease), and chronic malabsorption syndrome.


5. Cetilistat side effects


Cetilistat powder is considered safe but if you exceed the recommended cetilistat dosage or fail to follow instructions you experience some cetilistat side effects. These side effects may occur at the beginning but are mild and should go away with continued use of the drug. If they do not go away, you should contact your doctor.

The most common cetilistat side effects are;


Gas with discharge

Nasal congestion

Diarrhea

Headaches

Urgent and frequent bowel movements that might be hard to control

Oily spotting

Oily or fatty stools


Some rare but more serious cetilistat side effects might also occur. You should consult your doctor immediately when you notice the following adverse effects;

Jaundice (yellowing of eyes or the entire body)

Dark urine

Loss of appetite

Unusual fatigue

Severe stomach pain

Difficulty swallowing or breathing.



6. Cetilistat benefits


Cetilistat weight loss benefit in obesity management is the main use it is known for. There are however other cetilistat benefits that make it distinct and stand out among other weight loss drugs.

Below are some cetilistat benefits;


Help you maintain a healthy lifestyle through weight loss


Cetilistat is one of the great weight-loss drugs as well as an anti-obesity agent. In your normal life gaining excessive weight leads to an increase in size and body fat often referred to as being overweight or obese. The two conditions are associated with health issues such as type 2 diabetes mellitus, heart disease like stroke, high blood pressure, and certain cancers like colon and breast cancers.

The distinction between overweight and obese individuals is the body mass index (BMI). A person is considered to be overweight when the BMI is greater than or equal to 25 while a person with obesity has a BMI greater than or equal to 30.

Taking cetilistat will help your body to reduce the accumulation of fats thus maintaining a healthy BMI and consequently a healthy lifestyle. This is so because it lowers the chances of the life-threatening conditions associated with obesity.  


Helps in weight loss and reduction of glycosylated hemoglobin in obese diabetic patients


Diabetes and specifically type 2 diabetes also called diabetes mellitus is a common disorder in obese patients. Type 2 diabetes occurs when the body cells resist the proper effect of insulin, which is to direct the blood glucose into the cells. This leads to glucose accumulation in the blood.  obesity is known to greatly increase the occurrence of type 2 diabetes.

Glycosylated hemoglobin (hemoglobin to which glucose binds) is a measure of long-term diabetes mellitus control. The level of glycosylated hemoglobin (HbA1c) shows the average blood glucose over the past three months. The normal glycosylated hemoglobin level is 7 % but most people with diabetes can only achieve 9 %.

In a 12-week, randomized, clinical study with a placebo control, obese patients with type 2 diabetes were given cetilistat (40, 80, or 120mg three times daily). They were also to stick to a hypocaloric diet. Cetilistat was found to significantly reduce weight as well as reduce glycosylated hemoglobin (HbA1c). It was also noted that cetilistat was well tolerated.


Cetilistat is well tolerated


Apart from its effectiveness in reducing weight and managing obesity, there is more to it. Cetilistat is well tolerated in the body with mild to moderate side effects which are manageable and may disappear with continued cetilistat use.

Although most of us go for effectiveness in medication, it also good to look for a drug that is tolerable in your body.

In phase 2 clinical study was conducted for 12 weeks using both cetilistat and the commonly available orlistat. The two weight-loss drugs were found to be effective in reducing weight, reducing the glycosylated hemoglobin as well as reducing the waist circumference. Also, cetilisat was found to well-tolerated than orlistat, with fewer and less severe side effects associated with cetilistat.




Helps you achieve your goals within a short time


Weight loss is a short-term goal that can be achieved through a change of diet and accompanied by regular exercise. However, maintaining a healthy weight is a long-term goal.

Your doctor may recommend a prescription weight loss drug when a healthy lifestyle (diet and exercise) does not achieve the intended weight loss. Cetilistat is one of the medications that can be used along with a low-fat diet and regular exercise. Unlike other anti-obesity drugs that take a long time to achieve significant weight loss, cetilistat takes about 12 weeks to provide the desired weight.


May help lower your cholesterol level


Cholesterol refers to a waxy substance. It is required by your body to build cells however, too much may cause issues in the body.

Cholesterol is made by the liver while some come from the foods you consume such as meat, poultry, and full-fat dairy products. There are 2 types of cholesterol. Low-density lipoprotein (LDL) cholesterol or the  bad cholesterol and high-density lipoprotein or the good cholesterol. The LDL contributes to fatty build-up in arteries hence increase the risk of heart diseases such as stroke and heart attack.

Being obese increases your risk of high cholesterol levels. Obesity increases the amount of LDL cholesterol by altering your body s response to the fats you consume. The inflammation caused by obesity also decreases your body s response to changes in dietary fat intake. In addition, insulin resistance is also common in patients with obesity. This also affects the normal process of fats in your body.

Cetilistat can reduce total cholesterol as well as LDL cholesterol.

In a study involving rats, cetilistat administered orally was found to ameliorate obesity and total cholesterol.


Reduces the risk of cardiovascular disease


Cardiovascular disease is a collective word referring to disorders that affect the heart or blood vessels. Cardiovascular disease includes coronary artery diseases such as heart attack and angina, stroke, heart failure, and rheumatic heart disease among others.

The cause of cardiovascular disease varies depending on the specific disorder. For instance, coronary artery disease, stroke, and periphery artery disease may be caused by high blood pressure, type 2 diabetes, smoking, lack of exercise, obesity, and poor diet. Obesity is estimated to account for approximately 5 % of cardiovascular disease.

Cetilistat, therefore, reduces the risk of cardiovascular disease by treating obesity and encouraging a healthy diet that plays role in preventing the occurrence of heart disorders.

In a 12 week randomized, double-blind study involving obese patients with diabetes mellitus, cetilistat was administered at 40, 80, or 120 mg three times daily. The participants were also advised to maintain a low-fat diet during the study period.

This study reported a significant weight reduction as well as improved glycemic control. In addition, there was a significant reduction in waist circumference which one of the risk factors in cardiovascular disease.


May lower your blood pressure


High blood pressure also referred to as hypertension is a condition in which the force of blood against the arteries walls stays elevated over some time. Hypertension is dangerous as it forces the heart to work too hard leading to the hardening of the arteries.

Hypertension is associated with some life-threatening diseases such as stroke, kidney, and liver diseases among others.  

Being overweight or obese raises your chances of developing high blood pressure. Your blood pressure increases with an increase in weight.

It, therefore, means that losing weight is one of the ways to lower your blood pressure. This is where cetilistat comes in because it leads to significant weight loss over a short time.


7. Where can I buy Cetilistat?


If you consider using cetilistat buy online at the comfort of your home. Cetilistat powder is available online in cetilistat suppliers or cetilistat manufacturers stores. Wuhan Wingroup is one of the cetilistat manufacturers who sell quality products with very good customer service.

When buying cetilistat powder or otherwise cetilistat capsules from Wingroup or other cetilistat suppliers carefully check the labels for proper use of the drug. Consider the recommended cetilistat dosage as directed by the cetilistat manufacturer but also follow recommendations by your health care provider.

Reading cetilistat reviews from personal experiences may assist you to get a better understanding of its efficacy as well as safety. Most customers of cetilistat buy online and may leave cetilistat reviews based on their personal experiences.

Cetilistat price is also a consideration when you want to buy it. Wingroup is one of the cetilistat suppliers who may be offering a competitive cetilistat price. However, cetilistat prices should not blind you to choose a poor quality product.

Buying from the comfort of your home may be tempting to make hasty purchases, however, you still need to make proper arrangements to know the availability of the drugs you require beforehand.


References


1. Bryson, A., de la Motte, S., & Dunk, C. (2009). Reduction of dietary fat absorption by the novel gastrointestinal lipase inhibitor cetilistat in healthy volunteers. British journal of clinical pharmacology, 67(3), 309每315. https://doi.org/10.1111/j.1365-2125.2008.03311.x.

2. Hainer V. (2014). Overview of new antiobesity drugs. Expert opinion on pharmacotherapy, 15(14), 1975每1978. https://doi.org/10.1517/14656566.2014.946904.

3. Kopelman, P., Groot, G., Rissanen, A., Rossner, S., Toubro, S., Palmer, R., Hallam, R., Bryson, A., & Hickling, R. I. (2010). Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (Xenical). Obesity (Silver Spring, Md.), 18(1), 108每115. https://doi.org/10.1038/oby.2009.155.

4. Kopelman, P; Bryson, A; Hickling, R; Rissanen, A; Rossner, S; Toubro, S; Valensi, P (2007). "Cetilistat (ATL-962), a novel lipase inhibitor: A 12-week randomized, placebo-controlled study of weight reduction in obese patients". International Journal of Obesity. 31 (3): 494每9. doi: 10.1038/sj.ijo.0803446. PMID 16953261.

5. Padwal, R (2008). "Cetilistat, a new lipase inhibitor for the treatment of obesity". Current Opinion in Investigational Drugs. 9 (4): 414每 PMID 18393108.

6. Yamada Y, Kato T, Ogino H, Ashina S, Kato K (2008). "Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats". Hormone and Metabolic Research. 40 (8): 539每 doi:10.1055/s-2008-1076699. PMID 18500680. S2CID 29076657.


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