RAD140 CAS 118237-47-0

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Product  NameRAD140
SynonymsRAD140Whitepowder99%;Testolone;OralSARMSMuscleBuildingRad140/TestoloneForIncreasingMuscleMass;LowestpriceofRAD140CASNO.1182367-47-0;2-Chloro-Chemicalbook4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile;SARMRAD-140Powderwhnohe_carolin(at)163.com;CS-2554
CAS NO118237-47-0
Molecular FormulaC20H16ClN5O2
Molecular Weight393.83
Melting point N/A
Boiling Point687.765 C at 760mmHg
Flash Point369.734.3 C
Density 1.40.1 g/cm3
Purity99.5%(HPLC)
GradePharmaceutical Grade
Solubilityit is soluble in organic solvents such as ethanol, DMSO, and  dimethyl formamide (DMF)
AppearanceWhite powder
Storageat room temperature and out of direct sunlight
Packing and ShippingPacking: Drum / Aluminum Foil  Bag / According to customer's requiement                                                          Shipping: 3-5 working days after receive payment,  by Fedex,UPS,EMS,DHL,Sea and air transport
UsageIt is beneficial for the  treatment of lean muscle mass and/or bone density increase, such as the  treatment of weight loss caused by cancer cachexia, muscle weakness and  osteoporosis, and also for the treatment of breast cancer.


RAD-140(118237-47-0) Description


RAD 140, also known as Testolone, is a type of investigational Selective Androgenic Receptor Modulator (SARMs) that mimics the positive effects of an anabolic steroid, without carrying along the harmful effects linked with it. Androgens are natural hormones present in both male and female bodies in different ranges that are responsible for developing male characteristics and controlling the growth of secondary sex organs. RAD 140 work by selectively binding to the androgen receptors and boosting performance. RAD 140 Testolone is said to be highly effective in enhancing lean muscle growth, boosting strength and accelerating recovery. Though RAD 140 is a popular SARM, but it is important to know that Testolone is an investigational SARM.


RAD-140(118237-47-0) Mechanism of Action


RAD 140 is a powerful SARM and its characteristics are much similar to those of steroids. RAD 140 has very unique working mechanism as they dont have androgenic properties, but they carry very similar anabolic properties to testosterone and other steroids. As a result, your body will get an enhanced capacity to increase the amount of protein synthesis, which is a necessary part of building muscle mass. With boosted protein synthesis, your body will work towards building more muscle with reduced recovery time. It means that you can work super hard in the gym with better and faster recovery time after workout. As RAD 140 is not an androgen, it doesnt come with the negative effects like steroids. Androgens can affect your bodys natural production of testosterone in the long run and can have devastating impacts on your internal organs and fertility levels.


RAD-140(118237-47-0) Application


RAD140 is an investigational selective androgen receptor modulator (SARM) developed as a future substitute of exogenous Testosterone replacement therapy (TRT). Some of the benefits under investigation are for the treatment of conditions such as muscle wasting and skeleton wasting (Osteoporosis).


RAD-140(118237-47-0) Side Effects & Warning


Low testosterone levels

It is a common side effect that can occur from using any kind of drug that increases your bodys testosterone levels

If you use supplements for a long period of time, it can negatively impact your bodys natural production of testosterone

Your body can begin to depend on this external source of testosterone, and essentially shuts down its natural production

When your cycle of the drug then stops, you can be left with very low levels of testosterone


Nausea

It is a minor but common side effect of using SARMS for the first time. It can be an indication that your dosage of RAD 140 is too high

Alternatively, it can be your bodys way of telling you that it needs time to adjust to this new drug


Acne

Another minor and temporary side effect of using a drug like RAD 140 or other steroids is an increase in ance

This is likely due to the fact that your body is adjusting to fluctuating hormone levels

It may take a few weeks or months to settle down, but it also may be an indication that your dosage is too high


Liver damage

This more serious side effect has been discovered very recently during the preclinical trials of RAD 140, as well as other SARMS

The study was the first one to find results of significant liver damage that was caused by the use of SARMS

However, this damage was temporary, and within twelve months, it had been treated after the patients stopped using the SARMS.


Reference


1. Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ (April 2014). "Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats". Endocrinology. 155 (4): 1398C406. doi:10.1210/en.2013-1725. PMC 3959610. PMID 24428527.

2. Hamson DK, Wainwright SR, Taylor JR, Jones BA, Watson NV, Galea LA (September 2013). "Androgens increase survival of adult-born neurons in the dentate gyrus by an androgen receptor-dependent mechanism in male rats". Endocrinology. 154 (9): 3294C304. doi:10.1210/en.2013-1129. PMID 23782943.

3. Miller CP, Shomali M, Lyttle CR, O'Dea LS, Herendeen H, Gallacher K, et al. (February 2011). "Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140". ACS Medicinal Chemistry Letters. 2 (2): 124C9. doi:10.1021/ml1002508. PMC 4018048. PMID 24900290.

4. Yu Z, He S, Wang D, Patel HK, Miller CP, Brown JL, Hattersley G, Saeh JC (December 2017). "Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action". Clinical Cancer Research. 23 (24): 7608C7620. doi:10.1158/1078-0432.CCR-17-0670. PMID 28974548.



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