GW0742 CAS 317318-84-6

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Product  NameGW0742
Synonyms2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy);GW0742X;GW610742;GWdelta0742;2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenChemicalbooko;GW0742;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETICACID;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETICACID
CAS NO317318-84-6
Molecular FormulaC21H17F4NO3S2
Molecular Weight471.49
Melting point 134.5-135.5 C
Boiling Point591.560.0 C(Predicted)
Flash Point311.532.9 C
Density 1.460.1 g/cm3(Predicted)
Purity98% (HPLC)
GradePharmaceutical Grade
SolubilityChloroform (Slightly), Methanol  (Slightly)
AppearanceWhite Powder
Storagestore at dry and cool place
Packing and ShippingPacking: Drum / Aluminum Foil  Bag / According to customer's requiement                                                        Shipping: 3-5 working days after receive payment, by  Fedex,UPS,EMS,DHL,Sea and air transport
UsageIt is the best in terms of  endurance, energy, endurance and any type of performance improvement

GW0742 317318-84-6 Description

GW0742 (also known as GW610742) is a PPAR/ agonist that is investigated for drug use.GW0742 is mixed PPAR-B agonist antagonist depending on its dosage.GW0742 has weak activity on multiple nuclear receptors as well. It is antagonistic at androgen receptors and VDR.In silico modelling suggest that it has effects on thyroid hormone receptors.Multiple derivaties of GW0742 core structure has been developed. One of the compound,

which has thiazole ring replaced with an oxazole ring inhibited VDR-meditated transcription with IC50 of 660 nM.Other novel analgos which are more potent than GWO742 with reduced toxicity has been developed as well.


GW0742 317318-84-6 Mechanism of Action

GW0742 attenuated the increased HOMA-IR in diabetic rats fed a fructose-rich diet. This action was blocked by GSK0660 at the dose sufficient to inhibit PPAR-. Improvement of IR by GW0742 was also characterized in diabetic rats using hyperinsulinemic euglycemic clamping. Additionally, an increase of insulin sensitivity due to GW0742 was observed in these diabetic rats. Moreover, GW0742 reduced the hyperglycemia in T1DM rats lacking insulin. Western blotting analysis indicated that GW0742 reversed the decrease in GLUT4 and markedly reduced the increased PEPCK in liver.


GW0742 317318-84-6 Application

Better workout results:GW0742 is a great drug when it comes to increasing fat degeneration inside the body. This makes it very beneficial for anyone trying to get rid of their body fat throughout the exercise and other physical activities.

More energy: The break-down of the stored body fats by GW0742 results in more energy production in the body. This is especially helpful for anyone with a high physical activity rate. More energy production helps people feel less tired and keeps their stamina active for longer.

Improved heart health: GW0742s regular intake helps your heart and circulatory system in several ways. It strengthens the valves, helps improve the rate of blood flow, keeps the arteries clear of any clogging, and makes the cardiovascular muscles stronger.

Lesser inflammation: GW0742 is very effective in avoiding body inflammation and in keeping the veins and vessels healthy.

Better kidney and liver: A faster breakdown of fats and the maintenance of body lipids help GW0742 in keeping the kidneys and liver healthier and working normally for a long.  Lesser fats in the body and reduced chances of inflammation as a result of GW0742 intake diminish the chances of disease development in any of these organs.

Reduced chance of skeletal system problems:GW0742 avoids the inflammation and fibrillation in bones and cartilage. This makes it a good agent to keep the skeleton healthier for a long, reducing any chance of related diseases.


Benefits of GW0742 317318-84-6

Lowers the bodys cholesterol levels

A not-so-recent study performed on rats to investigate the effects of GW0742 revealed it as a great drug for maintaining the bodys cholesterol levels. The drug, once it reaches inside the body to the target points, reverses the process of cholesterol transport to blood.

This way, most of the cholesterol taken by the body is forced towards the digestive tracts and later gets excreted from the body. The reduction in the bodys cholesterol levels (when it is high) often saves the body from many severe health issues, including heart problems and diabetes.

Handles body lipids better

Lipids, especially tri-glycerides, need to be maintained on strict levels inside the body. Any failure to maintain the lipid profile can cause severe damage to your heart. Increased lipid concentration in the body can often prove fatal. This concentration is very difficult to be brought down once the lipids have accumulated inside.

Cures inflammation in the Gut region

Gut inflammation is one of the worst possible swelling issues the human body has to go through. Most of the time, people get to know their guts inflammation only when the condition has worsened. This leads the patient to go through a lot of pain and may also prove fatal sometimes.

Thankfully, some amounts of GW0742, if taken regularly, can help with gut inflammation by decreasing the swelling. Using this drug can also reduce the painful sensations that arise from an inflamed gut, thus bringing the patient a lot of relief.elevated transaminases, higher cholesterol levels, and loss of red and white blood cells.


Reference

1. "Cayman Chemical GW0742". Retrieved 31 Mar 2013.

2. Smith SA, Monteith GR, Robinson JA, Venkata NG, May FJ, Roberts-Thomson SJ (July 2004). "Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research. 77 (2): 240C9. doi:10.1002/jnr.20153. PMID 15211590. S2CID 21295375.

3. Haskova Z, Hoang B, Luo G, Morgan LA, Billin AN, Barone FC, et al. (July 2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARbeta/delta ligand GW0742". Inflammation Research. 57 (7): 314C21. doi:10.1007/s00011-007-7157-4. PMID 18622687. S2CID 25631088.

4. Sznaidman ML, Haffner CD, Maloney PR, Fivush A, Chao E, Goreham D, Sierra ML, LeGrumelec C, Xu HE, Montana VG, Lambert MH, Willson TM, Oliver WR, Sternbach DD (May 2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor (PPAR)--synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters. 13 (9): 1517C21. doi:10.1016/s0960-894x(03)00207-5. PMID 12699745.




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