SR9009 CAS 1379686-30-2

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Product  NameSR9009
SynonymsSR9009sarms,whnohe_lucy(at)163.com;Ethyl3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate;CS-2027;SR9009Powderwhnohe_Chemicalbookcarolineat163.com;Stenabolic(SR9009);SR9009;3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylicacidethylester;STENABOLIC
CAS NO1379686-30-2
Molecular FormulaC20H24ClN3O4S
Molecular Weight437.94
Melting point 79-81C
Boiling Point547.245.0 C(Predicted)
Flash Point284.728.7C
Density 1.3270.06 g/cm3(Predicted)
Assay99%
GradePharmaceutical Grade
SolubilityDMSO (Slightly), Methanol  (Slightly, Sonnicated)
AppearanceWhite Powder
Storagestore in tight,light resistance  containers in a cool place
Packing and ShippingPacking: Drum / Aluminum Foil  Bag / According to customer's requiement                                                          Shipping: 3-5 working days after receive payment, by  Fedex,UPS,EMS,DHL,Sea and air transport
UsageIt can increase weight loss,  increase endurance, lower blood cholesterol, reduce inflammation, and reduce  anxiety


SR9009 (1379686-30-2) Description


SR9009, also known as Stenabolic, Activation of Rev-ErbA- by SR9009 in mice increases exercise capacity by increasing mitochondria counts in skeletal muscle.SR9009 has been described as an agonist for circadian nuclear receptors REV-ERB and -, and its pleotropic biological effects have been attributed to REV-ERBs in numerous publications, as well as websites selling the compound illicitly to the lay public. Here, a conditional REV-ERB/ double-deletion mouse model was generated and used to test the specificity of SR9009 and a related compound. SR9009 was found to exert REV-ERBCindependent effects on proliferation, metabolism, and gene transcription in 2 different cell types depleted of REV-ERBs. Therefore, effects of these drugs cannot be exclusively attributed to its actions on REV-ERBs, and it is imperative that investigators using the drug be made aware of this.


SR9009 (1379686-30-2) Mechanism of Action


SR9009 binds to Rev-erb, a natural protein in the body that influences lipid and glucose metabolism in the liver, inflammatory responses, and fat-storing cells. By binding to Rev-erb, SR9009 can kickstart metabolism with another pleasant side-effect: increased muscle strength.


SR9009 (1379686-30-2) Application


Increases glucose metabolism

SR9009 influences the metabolism of glucose in the liver. This results in more glucose being absorbed in the skeletal muscle instead of being stored as fat.


Increases calorie metabolism

SR9009 allows for the efficient metabolism of calories entering your body through food. This not only ensures that no fat is stored in your body but also helps reduce the amount of fat that is already stored in your body.


Improves basal metabolic rate

SR9009 has the ability to make your body respond as if it were in a state of constant exercise, increasing the basal metabolic rate. Even without engaging in any exercise, your metabolism will remain high while you are using the SR9009.


The good thing about SR9009 fat loss is that the supplement not only helps you to effectively lose weight, whether you are obese or overweight, but it also helps you maintain ideal body weight. In addition, unlike most fat burners on the market, the SR9009 will keep your metabolism high without necessarily affecting your central nervous system.


SR9009 (1379686-30-2) Side Effects & Warning


SR9009 is not hormonally estrogenic or androgenic and is safe for both men and women. As of now, there are no known SR9009 side effects. However, it is not unlikely that some side effects will occur. If you experience any discomfort during the use of the medicine, it is advisable to stop using it immediately and talk to your doctor about it. To find out how your body reacts to SR9009, start with a small dose and slowly increase from 20mg to 30mg per day. This would let you know how this drug works best for you.


Reference


1. Dodson B (2013-08-20). "New drug mimics the beneficial effects of exercise". Health and Wellbeing. Gizmag. Retrieved 2013-08-21.


2. Solt LA; Wang Y; Banerjee S; Hughes T; Kojetin DJ; Lundasen T; Shin Y; Liu J; Cameron MD; Noel R; Yoo SH; Takahashi JS; Butler AA; Kamenecka TM; Burris TP (May 2012). "Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists". Nature. 485 (7396): 62C8. Bibcode:2012Natur.485...62S. doi:10.1038/nature11030. PMC 3343186. PMID 22460951.


3. Woldt E; Sebti Y; Solt LA; Duhem C; Lancel S; Eeckhoute J; Hesselink MK; Paquet C; Delhaye S; Shin Y; Kamenecka TM; Schaart G; Lefebvre P; Nevire R; Burris TP; Schrauwen P; Staels B; Duez H (August 2013). "Rev-erb- modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy". Nat. Med. 19 (8): 1039C46. doi:10.1038/nm.3213. PMC 3737409. PMID 23852339. Lay summary C Voice of America (2013-07-19).



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